Cognitive behavior of rats with thalamic lesions

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Tomie, Jo-Anne B.
University of Lethbridge. Faculty of Arts and Science
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Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 1994
The objective of this thesis was to test the idea that medial thalamic nuclei are part of a "memory circuit" in the brain. Rats received lesions of the anterior (ANT) or medial dorsal (MD) thalamic nuclei and were tested on two spatial tasks, a nonspatial configural task, and spontaneous and amphetamine-induced acitivity. The thalamic rats were impaired on the spatial and conifural tasks, ans some of the thalamic groups were slightly hyperactive after administration of amphertamine. The deficits were not large and could not be unequivocally attributed to the ANT or MD damage. The results question the role of the ANT or MD in the behaviors studied. It is suggested that the deficits obtained after thalamic damage may be nonspecific and it is concluded that the results do not support the notion that thalamic structures have a primary role in memory.
xi, 187 leaves : ill., plates ; 29 cm.
Dissertations, Academic , Memory -- Physiological aspects , Thalamus -- Physiology