A novel animal model of hippocampal cognitive deficits, slow neurodegeneration, and neuroregeneration
Spanswick, Simon C.
Sutherland, Robert J.
Long-term adrenalectomy (ADX) results in an extensive and speciﬁc loss of dentate gyrus granule cells in the hippocampus of adult rats. This loss of granule cells extends over a period of weeks to months and ultimately results in cognitive deﬁcits revealed in a number of tasks that depend on intact hippocampal function. The gradual nature of ADX-induced cell death and the ensuing deﬁcits in cognition resemble in some important respects a variety of pathological conditions in humans. Here, we characterize behavioural and cellular processes, including adult neurogenesis, in the rat ADX model.We also provide experimental evidence for a neurogenic treatment strategy by which the lost hippocampal cells may be replaced, with the goal of functional recovery in mind.
Sherpa Romeo green journal. Open access article. Creative Commons Attribution License applies.
Hippocampal , Long-term adrenalectomy , Cognitive deficits , Neurodegeneration , Neuroregeneration , Animal model , Granule cell loss
Spanswick, S. C., Lehmann, H., & Sutherland, R. J. (2011). A novel animal model of hippocampal cognitive deficits, slow neurodegeneration, and neuroregeneration. Journal of Biomedicine and Biotechnology, article 527201. doi:10.1155/2011/527201