A novel animal model of hippocampal cognitive deficits, slow neurodegeneration, and neuroregeneration

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dc.contributor.authorSpanswick, Simon C.
dc.contributor.authorLehmann, Hugo
dc.contributor.authorSutherland, Robert J.
dc.date.accessioned2019-04-04T03:46:21Z
dc.date.available2019-04-04T03:46:21Z
dc.date.issued2011
dc.descriptionSherpa Romeo green journal. Open access article. Creative Commons Attribution License applies.en_US
dc.description.abstractLong-term adrenalectomy (ADX) results in an extensive and specific loss of dentate gyrus granule cells in the hippocampus of adult rats. This loss of granule cells extends over a period of weeks to months and ultimately results in cognitive deficits revealed in a number of tasks that depend on intact hippocampal function. The gradual nature of ADX-induced cell death and the ensuing deficits in cognition resemble in some important respects a variety of pathological conditions in humans. Here, we characterize behavioural and cellular processes, including adult neurogenesis, in the rat ADX model.We also provide experimental evidence for a neurogenic treatment strategy by which the lost hippocampal cells may be replaced, with the goal of functional recovery in mind.en_US
dc.description.peer-reviewYesen_US
dc.identifier.citationSpanswick, S. C., Lehmann, H., & Sutherland, R. J. (2011). A novel animal model of hippocampal cognitive deficits, slow neurodegeneration, and neuroregeneration. Journal of Biomedicine and Biotechnology, article 527201. doi:10.1155/2011/527201en_US
dc.identifier.urihttps://hdl.handle.net/10133/5321
dc.language.isoen_USen_US
dc.publisherHindawi Publishingen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.publisher.institutionTrent Universityen_US
dc.publisher.institutionUniversity of Lethbridgeen_US
dc.publisher.urlhttps://dx.doi.org/10.1155/2011/527201
dc.subjectHippocampalen_US
dc.subjectLong-term adrenalectomyen_US
dc.subjectCognitive deficitsen_US
dc.subjectNeurodegenerationen_US
dc.subjectNeuroregenerationen_US
dc.subjectAnimal model
dc.subjectGranule cell loss
dc.subject.lcshAnimal models in research
dc.subject.lcshHippocampus (Brain)--Research
dc.subject.lcshCell death
dc.subject.lcshDentate gyrus--Research
dc.subject.lcshBrain--Research
dc.subject.lcshAdrenalectomy
dc.titleA novel animal model of hippocampal cognitive deficits, slow neurodegeneration, and neuroregenerationen_US
dc.typeArticleen_US
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