The effects of rat strain, sex and THC on brain and behaviour : factors that alter the sensitivity to drugs of abuse

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dc.contributor.authorKeeley, Robin J.
dc.contributor.supervisorMcDonald, Robert J.
dc.date.accessioned2014-10-10T18:39:16Z
dc.date.available2014-10-10T18:39:16Z
dc.date.issued2014
dc.degree.levelPh.Den_US
dc.degree.levelPhD
dc.description.abstractThe laboratory rat has been used for over a century, and through directed and accidental mechanisms, different rat strains were developed. This study examined the effect of strain and sex on metrics of brain size and function and in response to amphetamine. In addition to strain and sex, the adolescent period is sensitive to drugs of abuse, such as marijuana. This study also examined the effects of post-pubertal exposure of the psychoactive component of marijuana, Δ9-tetrahydrocannabinol (THC), to males of females of two rat strains. Rats were assessed for developmental and adult differences in brain and behaviour, including alterations in sensitivity to amphetamine. This study also implemented parametric and nonparametric statistical tests. Strain and sex contributed to behavioural and neuroanatomical differences between groups exposed to THC during adolescence, and drug experience in adolescence produced strain- and sex-specific effects. This study highlights the background-dependent effects of THC on brain and behaviour.en_US
dc.identifier.urihttps://hdl.handle.net/10133/3532
dc.language.isoen_CAen_US
dc.proquest.subject0602en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, 2014en_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectRat strainsen_US
dc.subjectTHCen_US
dc.subjectDrugs of abuseen_US
dc.subjectBehavioural differences
dc.subjectStrain and sex differences
dc.subject.lcshTetrahydrocannabinol
dc.subject.lcshRats as laboratory animals
dc.subject.lcshRats--Behavior
dc.subject.lcshBrain--Effect of drugs on
dc.subject.lcshDissertations, Academic
dc.titleThe effects of rat strain, sex and THC on brain and behaviour : factors that alter the sensitivity to drugs of abuseen_US
dc.typeThesisen_US
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