Small binding-site clearance delays are not negligible in gene expression modeling

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dc.contributor.authorTrofimenkoff, Elizabeth A. M.
dc.contributor.authorRoussel, Marc R.
dc.date.accessioned2020-09-28T21:33:17Z
dc.date.available2020-09-28T21:33:17Z
dc.date.issued2020
dc.descriptionAccepted author manuscript.en_US
dc.description.abstractDuring the templated biopolymerization processes of transcription and translation,a macro molecular machine, either an RNA polymerase or a ribosome, binds to a specific site on the template. Due to the sizes of these enzymes,there is a waiting time before one clears the binding site and another can bind.These clearance delays are relatively short, and one might think that they could be neglected. However,in the case of transcription, these clearance delays are associated with conservation laws,resulting in surprisingly large effects on the bifurcation diagrams in models of gene expression networks.We study an example of this phenomenon in a model of a gene regulated by a non-coding RNA displaying bistability. Neglecting the binding-site clearance delays in this model can only be compensated for by making ad hoc, unphysical adjustments to the model’s kinetic constants.en_US
dc.description.peer-reviewYesen_US
dc.identifier.citationTrofimenkoff, E. A. M., & Roussel, M. R. (2020). Small binding-site clearance delays are not negligible in gene expression modeling. Mathematical Biosciences, 325, 108376. https://doi.org/10.1016/j.mbs.2020.108376en_US
dc.identifier.urihttps://hdl.handle.net/10133/5785
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.publisher.departmentDepartment of Chemistry and Biochemistryen_US
dc.publisher.facultyArts and Scienceen_US
dc.publisher.institutionUniversity of Lethbridgeen_US
dc.publisher.urlhttps://doi.org/10.1016/j.mbs.2020.108376en_US
dc.subjectGene expression modelingen_US
dc.subjectDelaysen_US
dc.subjectBinding-site clearanceen_US
dc.subjectProcessive enzymesen_US
dc.titleSmall binding-site clearance delays are not negligible in gene expression modelingen_US
dc.typeArticleen_US
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