An exploratory cohort study of serum estradiol, testosterone, osteoprotegerin, interleukin-6, calcium, and magnesium as potential biomarkers of cervical spondylosis

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dc.contributor.authorIgwe, Augustine A.
dc.contributor.authorOnyeso, Ogochukwu K.
dc.contributor.authorAdandom, Israel
dc.contributor.authorOnyeso, Kelechi M.
dc.contributor.authorAnyachukwu, Canice C.
dc.contributor.authorAwosoga, Olu A.
dc.contributor.authorEzema, Charles I.
dc.contributor.authorOkoye, Goddy C.
dc.date.accessioned2023-08-11T20:59:13Z
dc.date.available2023-08-11T20:59:13Z
dc.date.issued2023
dc.descriptionOpen access article. Creative Commons Attribution 4.0 International license (CC BY 4.0) applies
dc.description.abstractBackground: Exploration of biomarkers for debilitating diseases such as cervical spondylosis is important to revolutionize clinical diagnosis and management of such conditions. The study aimed to determine the correlation between neck pain and disability and serum levels of interleukin-6 (IL-6), osteoprotegerin (OPG), estradiol (E2), testosterone (TES), calcium (Ca), and magnesium (Mg) among individuals with symptomatic cervical spondylosis. Methods: This study was a cohort design. The participants were new referrals to two Nigerian physical therapy clinics. Participants’ neck pain intensity (PI), neck disability index (NDI), IL-6, OPG, E2, TES, Ca, and Mg were measured at baseline and after 13 weeks of follow-up. Data were analyzed using descriptive statistics, independent samples t test, Pearson’s correlation, and multiple linear regression. Results: Forty individuals aged 52.40 ± 8.60 years participated in the study. Women had significantly higher levels of IL-6 (t =  − 2.392, p = 0.026), OPG (t =  − 3.235, p = 0.005), E2 (t =  − 6.841, p = 0.001), but lower TES (t = 17.776, p = 0.001). There were no significant sex differences in PI and NDI. There were significant correlations between PI and OPG (r = 0.385, p < 0.001), NDI and OPG (r = 0.402, p < 0.001), and IL-6 (r = 0.235, p = 0.036). Significant predictors of PI were OPG (β = 0.442, p < 0.001) and E2 (β =  − 0.285, p = 0.011), and NDI were OPG (β = 0.453, p < 0.001), E2 (β =  − 0.292, p = 0.005), and IL-6 (β = 0.225, p = 0.024). Conclusion: High serum levels of IL-6 and OPG were associated with cervical spondylosis severity. However, high serum levels of E2 and TES correlated with lesser severity. Moreover, TES inversely correlated with the proinflammatory cytokines.
dc.description.peer-reviewYes
dc.identifier.citationIgwe, A. A., Onyeso, O. K., Adandom, I., Onyeso, K. M., Anyachukwu, C. C., Awosoga, O. A., Ezema, C. I., & Okoye, G. C. (2023). An exploratory cohort study of serum estradiol, testosterone, osteoprotegerin, interleukin-6, calcium, and magnesium as potential biomarkers of cervical spondylosis. Bulletin of Faculty of Physical Therapy, 28, Article 29. https://doi.org/10.1186/s43161-023-00141-y
dc.identifier.urihttps://hdl.handle.net/10133/6564
dc.language.isoen
dc.publisherSpringer
dc.publisher.facultyHealth Sciences
dc.publisher.institutionNational Orthopaedic Hospital (Enugu, Nigeria)
dc.publisher.institutionUniversity of Nigeria,
dc.publisher.institutionUniversity of Lethbridge,
dc.publisher.institutionEmerging Researchers and Professionals in Ageing-African Network
dc.publisher.institutionCedar Crest Hospital (Abuja, Nigeria)
dc.publisher.urlhttps://doi.org/10.1186/s43161-023-00141-y
dc.subjectBone remodeling
dc.subjectCytokines
dc.subjectDisability evaluation
dc.subjectIntervertebral disc degeneration
dc.subjectNeck pain
dc.subjectPhysical therapy
dc.subjectSex hormones
dc.subjectCervical spondylosis
dc.subject.lcshIntervertebral disk--Diseases
dc.subject.lcshSerum
dc.subject.lcshHormones, Sex
dc.subject.lcshCervical spondylotic myelopathy
dc.titleAn exploratory cohort study of serum estradiol, testosterone, osteoprotegerin, interleukin-6, calcium, and magnesium as potential biomarkers of cervical spondylosis
dc.typeArticle
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