What neurobiological mechanisms in hippocampus support rapid spatial learning with familiar information in the Morris Water Task?

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dc.contributor.authorRodriguez Diaz, Claudia
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorMcDonald, Robert J.
dc.date.accessioned2023-03-01T18:23:04Z
dc.date.available2023-03-01T18:23:04Z
dc.date.issued2022
dc.degree.levelMastersen_US
dc.description.abstractLong-term potentiation (LTP) is proposed as a molecular mechanism for learning and memory. N-methyl-D-aspartate receptors (NMDARs) are implicated during LTP and new learning. However, if rats are pre-trained prior to new learning NMDARs are not needed. Rather the activation of voltage gated calcium channels (VGCCs) and associated calcium influx might be responsible for LTP independent of NMDARs, and new learning with familiar information. The hypothesis was that to impair new learning with familiar information both NMDARs and VGCCs would need to be blocked. Rats were trained in a version of the Morris water task, consisting of a pre-training, mass-training, and a probe test. Before mass-training NMDARs and VGCCs were blocked in the hippocampus using AP5 and Verapamil, which are receptor antagonists. All rats were able to learn regardless of their experimental condition, which means that activation of NMDARs and VGCCs is not crucial for new spatial learning with familiar information.en_US
dc.identifier.urihttps://hdl.handle.net/10133/6442
dc.language.isoenen_US
dc.proquest.subject0317
dc.proquestyesYes
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Neurosicence
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)
dc.subjecthippocampus
dc.subjectMWT
dc.subjectneuroscience
dc.subjectbrain
dc.subjectspatial learning
dc.subjectmemory
dc.subjectrats
dc.subjectHippocampus (Brain)--Research
dc.subjectNeurosciences
dc.subjectLearning--Research
dc.subjectMemory--Research
dc.subjectCalcium channels--Research
dc.subjectLearning--Physiological aspects
dc.subjectMemory--Physiological aspects
dc.subjectSpace perception
dc.subjectRats as laboratory animals
dc.subjectDissertations
dc.subjectAcademic
dc.titleWhat neurobiological mechanisms in hippocampus support rapid spatial learning with familiar information in the Morris Water Task?
dc.typeThesisen_US
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