Behavioural and neuroanatomical evidence in episodic memory in the rat

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dc.contributor.authorO'Brien, Jamus
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorSutherland, Robert J.
dc.date.accessioned2016-02-24T23:01:44Z
dc.date.available2016-02-24T23:01:44Z
dc.date.issued2007
dc.degree.levelMastersen_US
dc.description.abstractIn an attempt to test the hypothesis that rat's can perform very similar behaviours to episodic memory in humans, we here develop a novel Paviovian conditioning procedure demonstrating integrated what- where-when representations. Rats explored two distinctive contexts, one in the morning and the other in the evening. Subsequently, either in the morning or the evening, they received a foot shock immediately upon entry into a third context that equally resembled the two explored contexts. When conditioned freezing was measured at an intermediate time of day, rats showed significantly more fear of the context congruent with the time of day of the foot shock. Thus, rats automatically form an integrated time-place memory that can be flexibly updated by future events, essential characteristics of episodic memory. Furthermore, it is shown that these memories rely upon some of the same neuroanatomical structures, including the medial prefrontal cortex and the hippocampus, as are specifically required for episodic memory in humans.en_US
dc.embargoNoen_US
dc.identifier.urihttps://hdl.handle.net/10133/4425
dc.language.isoen_CAen_US
dc.proquestyesNoen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Psychology & Neuroscienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectepisodic memoryen_US
dc.subjectmedial prefrontal cortexen_US
dc.subjecthippocampusen_US
dc.subjectnonhuman animalsen_US
dc.subjectrat modelen_US
dc.titleBehavioural and neuroanatomical evidence in episodic memory in the raten_US
dc.typeThesisen_US
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