Probing the impact of cholinergic circuits in functional recovery after focal cerebral ischemia

dc.contributor.authorMirza Agha, Behroo
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorMohajerani, Majid H.
dc.contributor.supervisorWhishaw, Ian Q.
dc.date.accessioned2019-01-14T18:48:15Z
dc.date.available2019-01-14T18:48:15Z
dc.date.issued2018
dc.degree.levelMastersen_US
dc.description.abstractThe current thesis investigated the role of acetylcholine in recovery from diaschisis and skilled hand movement following ischemic stroke in a mouse model of photothrombotic stroke. Mice were trained in skilled reaching task in which they were taught to use their hand to reach for, grasp, and eat a food pellet. They were implanted with a fiber optic in their nucleus basalis, the main source of cholinergic projections to the sensorimotor cortex, for optogenetic stimulation and an electrode in their motor cortex for local field potential recordings. Then they received photothrombotic stroke in their primary forelimb somatosensory cortex. The general findings are that upregulation of acetylcholine reduced diaschisis following photothrombotic stroke to primary forelimb somatosensory area as measured by endpoint scores. However, upregulation of acetylcholine did not improve skilled hand movements as measured by movement component scores and fictive eating analysis.en_US
dc.description.sponsorshipCanadian Institute of Health Research (CIHR)en_US
dc.embargoNoen_US
dc.identifier.urihttps://hdl.handle.net/10133/5267
dc.language.isoen_USen_US
dc.proquest.subject0317en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. : Universtiy of Lethbridge, Department of Neuroscienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectAcetylcholine -- Physiological effecten_US
dc.subjectCerebral ischemia -- Animal models -- Researchen_US
dc.subjectNeuroplasticity -- Researchen_US
dc.subjectCerebrovascular disease -- Researchen_US
dc.subjectSensorimotor cortex -- Researchen_US
dc.subjectacetylcholineen_US
dc.subjectbrain plasticityen_US
dc.subjecthand movementsen_US
dc.subjectischemic strokeen_US
dc.subjectphotothrombotic strokeen_US
dc.subjectsomatosensory forelimb areaen_US
dc.titleProbing the impact of cholinergic circuits in functional recovery after focal cerebral ischemiaen_US
dc.typeThesisen_US
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