Zebrin II / Aldolase C expression in the cerebellum of the western diamondback rattlesnake (Crotalus atrox)

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dc.contributor.authorAspden, Joel W.
dc.contributor.authorArmstrong, Carol L.
dc.contributor.authorGutierrez-Ibanez, Cristian I.
dc.contributor.authorHawkes, Richard
dc.contributor.authorIwaniuk, Andrew N.
dc.contributor.authorKohl, Tobias
dc.contributor.authorGraham, David J.
dc.contributor.authorWylie, Douglas R.
dc.date.accessioned2016-11-08T22:58:23Z
dc.date.available2016-11-08T22:58:23Z
dc.date.issued2015
dc.descriptionSherpa Romeo green journal: open accessen_US
dc.description.abstractAldolase C, also known as Zebrin II (ZII), is a glycolytic enzyme that is expressed in cerebellar Purkinje cells of the vertebrate cerebellum. In both mammals and birds, ZII is expressed heterogeneously, such that there are sagittal stripes of Purkinje cells with high ZII expression (ZII+), alternating with stripes of Purkinje cells with little or no expression (ZII-). The patterns of ZII+ and ZII- stripes in the cerebellum of birds and mammals are strikingly similar, suggesting that it may have first evolved in the stem reptiles. In this study, we examined the expression of ZII in the cerebellum of the western diamondback rattlesnake (Crotalus atrox). In contrast to birds and mammals, the cerebellum of the rattlesnake is much smaller and simpler, consisting of a small, unfoliated dome of cells. A pattern of alternating ZII+ and ZII- sagittal stripes cells was not observed: rather all Purkinje cells were ZII+. This suggests that ZII stripes have either been lost in snakes or that they evolved convergently in birds and mammals.en_US
dc.description.peer-reviewYesen_US
dc.identifier.citationAspden, J. W., Armstrong, C. L., Gutierrez-Ibanez, C. I., Hawkes, R., Iwaniuk, A. N., Kohl, T. ... Wylie, D. R. (2015). Zebrin II / Aldolase C expression in the cerebellum of the western diamondback rattlesnake (Crotalus atrox). PloS ONE, 10(2), e0117539. doi:10.1371/journal.pone.0177539en_US
dc.identifier.urihttps://hdl.handle.net/10133/4660
dc.language.isoen_CAen_US
dc.publisherPublic Library of Scienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.publisher.institutionUniversity of Albertaen_US
dc.publisher.institutionMount Royal Universityen_US
dc.publisher.institutionTechnische Universität Münchenen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.publisher.institutionUniversity of Lethbridgeen_US
dc.subjectAldolase Cen_US
dc.subjectZebrin IIen_US
dc.subjectZII expressionen_US
dc.subjectWestern diamondback rattlesnakeen_US
dc.subjectCerebellumen_US
dc.subjectPurkinje cellsen_US
dc.subjectZII stripesen_US
dc.titleZebrin II / Aldolase C expression in the cerebellum of the western diamondback rattlesnake (Crotalus atrox)en_US
dc.typeArticleen_US
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