Applications of manganese-enhanced magnetic resonance imaging in neuroscience

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dc.contributor.authorMcCreary, J. Keiko
dc.contributor.supervisorCross, Albert
dc.date.accessioned2013-05-14T22:44:15Z
dc.date.available2013-05-14T22:44:15Z
dc.date.issued2012
dc.degree.levelMasters
dc.descriptionxi, 84 leaves ; 29 cmen_US
dc.description.abstractManganese-Enhanced Magnetic Resonance Imaging (MEMRI) has proven itself to be a beneficial technique in the field of Neuroscience. This thesis applies MEMRI to studies in neuroscience by first establishing the limitations concerning the use of MEMRI in live rats. Experiment 1 used an osmotic pump for manganese (Mn) delivery to the lateral ventricles for acquisition of anatomical images using MEMRI. From my knowledge, this was the first method demonstrating slow infusion of Mn to the lateral ventricles. In Experiment 2, MEMRI was used for volumetric analysis the whole brain and hippocampus of prenatally stressed rats. To my knowledge, this study was the first to investigate the effect of generational prenatal stress on the structure of a rat’s brain using MEMRI and histology. Additionally, Experiment 2 investigated the use of a subcutaneous osmotic pump to deliver Mn for MEMRI. A summary on the use of MEMRI in Neuroscience concludes this thesis, with a discussion on the methods used and related technical considerations.en_US
dc.identifier.urihttps://hdl.handle.net/10133/3254
dc.language.isoen_USen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, c2012en_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectBrain -- Magnetic resonance imagingen_US
dc.subjectRats -- Effect of stress onen_US
dc.subjectMagnetic resonance imagingen_US
dc.subjectNeurosciencesen_US
dc.subjectDissertations, Academicen_US
dc.titleApplications of manganese-enhanced magnetic resonance imaging in neuroscienceen_US
dc.typeThesisen_US
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