Plasticity cascades and place cell activity differ in new spatial learning based on context familiarity

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dc.contributor.authorFraser, Ellen
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorMcDonald, Robert J.
dc.date.accessioned2020-09-02T17:35:53Z
dc.date.available2020-09-02T17:35:53Z
dc.date.issued2020
dc.degree.levelMastersen_US
dc.description.abstractIn these experiments I have studied the effects of context familiarity on new spatial learning on a protein, behavioural, and cellular scale. I found evidence that there is greater expression of plasticity products in MEC-connected regions of the HPC in novel context learning and LEC-connected regions of the HPC in familiar context learning. Also in this experiment I observed a greater effect in downstream proteins, supporting the convergence of these cascades. In the second set of experiments I introduced the dry-land contextual navigation task and demonstrated learning in it. Furthermore, I compared the results in this task with rats in a water-based task and found that win-stay tendencies differ between the two tasks. Finally, in the last experiment I assessed place-cell activity in dorsal CA1 in freely-behaving mice in the DCNT. I found evidence of global remapping but not encoding of the reward.en_US
dc.identifier.urihttps://hdl.handle.net/10133/5753
dc.language.isoen_USen_US
dc.proquest.subjectNeurosciences [0317]en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Neuroscienceen_US
dc.publisher.departmentNeuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectBrain plasticity and reorganizationen_US
dc.subjectCognitionen_US
dc.subjectDevelopmental neurobiologyen_US
dc.subjectLong-term Potentiationen_US
dc.subjectNeural circuitry -- Adaptationen_US
dc.subjectNeuroplasticityen_US
dc.titlePlasticity cascades and place cell activity differ in new spatial learning based on context familiarityen_US
dc.typeThesisen_US
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