I. Synthesis and ring-opening polymerization of cationic divalent metal complexes supported by NEN-pincer ligands (E = O, S, Se); II. Semisynthesis strategies for the generation of cannabinoids and related derivatives

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dc.contributor.authorWebb, Dylan James
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorHayes, Paul G.
dc.date.accessioned2022-06-23T22:22:20Z
dc.date.available2022-06-23T22:22:20Z
dc.date.issued2022
dc.degree.levelPh.Den_US
dc.description.abstractPart I describes the synthesis of neutral bis(phosphinimine) NEN-pincer ligands. The ligands vary at the neutral central donor, E, the flanking aromatic group, and P-substituents. Cationic alkyl and phenoxide zinc complexes of this ligand system were synthesized to understand the steric and electronic factors that govern the complexes capacity to serve as catalysts for the ring-opening polymerization of ε-caprolactone. Part II describes the semisynthetic strategies for the generation of the major cannabinoids (9THC and CBD), and the lower abundant cannabinoids 8THC and CBN. Lesser-known cannabinoids and related derivatives were also prepared. Their in vitro chemotherapeutic action to breast cancer cells is described, attempting to decipher a relationship to chemical structure. Other investigations include computational analysis and reduction of the ortho-quinoids. A quantitative NMR procedure was used to determine purity of cannabinoids extracted. Compounds were characterized via multi-dimensional and multi-nuclear NMR spectroscopy, elemental analysis, and, where possible, single-crystal X-ray diffraction experiments.en_US
dc.identifier.urihttps://hdl.handle.net/10133/6251
dc.language.isoen_USen_US
dc.proquest.subject0485en_US
dc.proquest.subject0488en_US
dc.proquest.subject0490en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Chemistry and Biochemistryen_US
dc.publisher.departmentDepartment of Chemistry and Biochemistryen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectcoordination chemistryen_US
dc.subjectorganic synthesisen_US
dc.subjectpolymer chemistryen_US
dc.subjectOrganic compounds--Synthesisen_US
dc.subjectCoordination compoundsen_US
dc.subjectPolymerizationen_US
dc.subjectCannabinoids--Synthesisen_US
dc.subjectCannabinoids--Derivativesen_US
dc.subjectLigandsen_US
dc.subjectDissertations, Academicen_US
dc.titleI. Synthesis and ring-opening polymerization of cationic divalent metal complexes supported by NEN-pincer ligands (E = O, S, Se); II. Semisynthesis strategies for the generation of cannabinoids and related derivativesen_US
dc.typeThesisen_US
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