Molecular mechanisms of radiation-induced bystander effects in vivo

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dc.contributor.authorKoturbash, Igor
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorKovalchuk, Olga
dc.date.accessioned2008-09-25T20:15:11Z
dc.date.available2008-09-25T20:15:11Z
dc.date.issued2008
dc.degree.disciplineBiological Sciences
dc.degree.fieldArts and Sciences
dc.degree.levelDoctor of Philosophy
dc.degree.levelPhD
dc.degree.subfieldSciences
dc.descriptionxiii, 208 leaves : ill. ; 29 cm.en
dc.description.abstractIonizing radiation (IR), along with being an important diagnostic and treatment modality, is a potent tumor-causing agent, and the risk of secondary radiation treatment-related cancers is a growing clinical problem. Now some studies propose to link secondary radiation-induced cancers to an enigmatic phenomenon of bystander effects, whereby the exposed cells send signal damage and distress to their naïve neighbors and result in genome destabilization and carcinogenesis. Yet, no data existed on the bystander effects in an organ other than an exposed one. With this in mind, we focused on the analysis of existence and mechanisms of radiation-induced bystander effects in vivo. We have found that bystander effects occur in vivo in distant skin and spleen following half-body or cranial irradiation. These bystander effects resulted in elevated DNA damage, profound dysregulation of epigenetic machinery, and pronounced alterations in apoptosis, proliferation and gene expression. Bystander effects also exhibited persistency and sex specificity. The results obtained while using the animal model systems can potentially be extrapolated to different animals and humans.en
dc.identifier.urihttps://hdl.handle.net/10133/664
dc.language.isoen_USen
dc.librarysymbolALU
dc.organizationUniversity of Lethbridge
dc.publisherLethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2008en
dc.publisher.departmentDepartment of Biological Sciencesen
dc.publisher.facultyArts and Scienceen
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en
dc.subjectDissertations, Academicen
dc.subjectIonizing radiation -- Health aspectsen
dc.subjectRadiation carcinogenesis -- Animal modelsen
dc.subjectRadiation carcinogenesisen
dc.subjectDNA -- Effect of radiation onen
dc.titleMolecular mechanisms of radiation-induced bystander effects in vivoen
dc.typeThesisen
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