Circadian disruption and breast cancer: an epigenetic link?
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Date
2015
Authors
Kochan, David Z.
Kovalchuk, Olga
Journal Title
Journal ISSN
Volume Title
Publisher
Impact Journals
Abstract
Breast cancer is already the most common malignancy affecting women worldwide, and evidence is mounting that breast cancer induced by circadian disruption (CD) is a warranted concern. Numerous studies have investigated various aspects of the circadian clock in relation to breast cancer, and evidence from these studies indicates that melatonin and the core clock genes can play a crucial role in breast cancer development. Even though epigenetics has been increasingly recognized as a key player in the etiology of breast cancer and linked to circadian rhythms, and there is evidence of overlap between epigenetic deregulation and breast cancer induced by circadian disruption, only a handful of studies have directly investigated the role of epigenetics in CD-induced breast cancer. This review explores the circadian clock and breast cancer, and the growing role of epigenetics in breast cancer development and circadian rhythms. We also summarize the current knowledge and next steps for the investigation of the epigenetic link in CD-induced breast cancer.
Description
Sherpa Romeo blue journal. Open access article. Creative Commons Attribution 3.0 License (CC BY 3.0) applies
Keywords
Breast cancer , Circadian disruption , Epigenetics , Circadian rhythms , Melatonin , Clock genes , DNA methylation , miRNAs , MicroRNAs
Citation
Kochan, D. Z., & Kovalchuk, O. (2015). Circadian disruption and breast cancer: An epigenetic link? Oncotarget, 6(19), 16866-16882. https://doi.org/10.18632/oncotarget.4343