Circadian disruption and breast cancer: an epigenetic link?

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dc.contributor.authorKochan, David Z.
dc.contributor.authorKovalchuk, Olga
dc.date.accessioned2019-01-24T18:49:41Z
dc.date.available2019-01-24T18:49:41Z
dc.date.issued2015
dc.descriptionSherpa Romeo blue journal. Open access article. Creative Commons Attribution 3.0 License (CC BY 3.0) appliesen_US
dc.description.abstractBreast cancer is already the most common malignancy affecting women worldwide, and evidence is mounting that breast cancer induced by circadian disruption (CD) is a warranted concern. Numerous studies have investigated various aspects of the circadian clock in relation to breast cancer, and evidence from these studies indicates that melatonin and the core clock genes can play a crucial role in breast cancer development. Even though epigenetics has been increasingly recognized as a key player in the etiology of breast cancer and linked to circadian rhythms, and there is evidence of overlap between epigenetic deregulation and breast cancer induced by circadian disruption, only a handful of studies have directly investigated the role of epigenetics in CD-induced breast cancer. This review explores the circadian clock and breast cancer, and the growing role of epigenetics in breast cancer development and circadian rhythms. We also summarize the current knowledge and next steps for the investigation of the epigenetic link in CD-induced breast cancer.en_US
dc.description.peer-reviewYesen_US
dc.identifier.citationKochan, D. Z., & Kovalchuk, O. (2015). Circadian disruption and breast cancer: An epigenetic link? Oncotarget, 6(19), 16866-16882. https://doi.org/10.18632/oncotarget.4343en_US
dc.identifier.urihttps://hdl.handle.net/10133/5276
dc.language.isoen_USen_US
dc.publisherImpact Journalsen_US
dc.publisher.departmentDepartment of Biological Sciencesen_US
dc.publisher.facultyArts and Scienceen_US
dc.publisher.institutionUniversity of Lethbridgeen_US
dc.publisher.urlhttps://doi.org/10.18632/oncotarget.4343
dc.subjectBreast canceren_US
dc.subjectCircadian disruptionen_US
dc.subjectEpigeneticsen_US
dc.subjectCircadian rhythmsen_US
dc.subjectMelatoninen_US
dc.subjectClock genes
dc.subjectDNA methylation
dc.subjectmiRNAs
dc.subjectMicroRNAs
dc.subject.lcshBreast--Cancer
dc.subject.lcshBreast--Cancer--Research
dc.titleCircadian disruption and breast cancer: an epigenetic link?en_US
dc.typeArticleen_US
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