Studying the spatiotemporal dynamics of cortical activity during REM-like state in urethane anesthetized mice

Simple item page
dc.contributor.authorNazariahangarkolaee, Mojtaba
dc.contributor.supervisorMohajerani, Majid H.
dc.contributor.supervisorTatsuno, Masami
dc.date.accessioned2018-01-23T16:22:23Z
dc.date.available2018-01-23T16:22:23Z
dc.date.issued2017
dc.degree.levelMastersen_US
dc.description.abstractSleep in mammals consists of two stages: non-rapid eye movement (NREM) and rapid eye movement (REM) sleep. NREM sleep is distinguished by slow and high-amplitude cortical EEG signals while REM sleep is characterized by “desynchronized” cortical rhythms. While until recently it was believed that cortical activity during REM sleep is globally desynchronized, using electrophysiological recording a recent study showed local slow waves in primary cortical areas during REM sleep (Funk et al, 2016). However, the sparse electrophysiological technique has been unable to resolve the regional structure of these activities. Here, we investigated local changes in neuronal activity during REM-like state using wide-field VSD imaging in the urethane model of sleep. We demonstrated that cortical desynchronization during REM-like state is indeed local; while midline and posterior areas typically show desynchronized patterns, anterior and lateral regions show synchronized activity. Our results also revealed that synchronized/desynchronized regions during individual REM-like episodes are dynamic.en_US
dc.description.sponsorshipNSERC BIP CREATEen_US
dc.embargoNoen_US
dc.identifier.urihttps://hdl.handle.net/10133/5012
dc.language.isoen_USen_US
dc.proquest.subject0317en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Neuroscienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectcortical desynchronizationen_US
dc.subjectneuronal activityen_US
dc.subjectNon-rapid eye movement sleepen_US
dc.subjectRapid eye movement sleepen_US
dc.subjectSleepen_US
dc.titleStudying the spatiotemporal dynamics of cortical activity during REM-like state in urethane anesthetized miceen_US
dc.typeThesisen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Nazariahangarkolaee_Mojtaba_MSC_2017.pdf
Size:
1.8 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
3.25 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Arts and Science, Faculty of
University of Lethbridge Theses