Investigating the structure-function relationship of anti-mitotic natural products in Canadian prairie plants

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dc.contributor.authorHealy Knibb, Shannon M.
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorGolsteyn, Roy
dc.date.accessioned2024-06-13T21:12:58Z
dc.date.available2024-06-13T21:12:58Z
dc.date.issued2024
dc.degree.levelMasters
dc.description.abstractThis thesis investigates Canadian prairie plants as sources of natural product compounds capable of inhibiting human cell division. Natural products present an opportunity to identify novel anti-mitotic compounds to address the lack of known inhibitors for many mitotic regulatory proteins. By biology-guided fractionation, we purified the natural products anemonin from Pulsatilla nuttalliana and (+)-6-tuliposide A from Erythronium grandiflorum, and this is the first report of their anti-mitotic activities. We then conducted a comparative study between pulchelloid A (from Gaillardia aristata), anemonin and (+)-6-tuliposide A, and identified unique mitotic arrest profiles, suggesting distinct protein targets and mechanisms of action consistent with the widespread relationship between structure and function in biology. The discovery of natural product inhibitors from Canadian prairie plant species holds tremendous potential for advancing our understanding of mitotic regulation and contributes to the development of targeted treatments for precision medicine.
dc.embargoNo
dc.identifier.urihttps://hdl.handle.net/10133/6784
dc.language.isoen
dc.proquestyesNo
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences
dc.publisher.departmentDepartment of Biological Sciences
dc.publisher.facultyArts and Science
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)
dc.subjectCanadian prairie plants
dc.subjectanti-mitotic compounds
dc.subjectnatural product compounds
dc.subjectcell division inhibitors
dc.subjectmitotic arrest profiles
dc.subjectmitotic regulation
dc.subjecttargeted treatments research
dc.subject.lcshDissertations, Academic
dc.subject.lcshPrairie plants--Canada
dc.subject.lcshPrairie plants--Therapeutic use--Research--Canada
dc.subject.lcshNatural products--Therapeutic use--Research
dc.subject.lcshBotany, Medical
dc.subject.lcshMedicinal plants
dc.subject.lcshCell cycle--Regulation--Research
dc.subject.lcshCancer cells--Growth--Regulation--Research
dc.subject.lcshMateria medica, Vegetable
dc.subject.lcshAntimitotic agents--Research
dc.subject.lcshCompositae--Therapeutic use--Research
dc.subject.lcshRanunculaceae--Therapeutic use--Research
dc.subject.lcshLiliaceae--Therapeutic use--Research
dc.titleInvestigating the structure-function relationship of anti-mitotic natural products in Canadian prairie plants
dc.typeThesis
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