Mathematical modeling of eukaryotic gene expression

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dc.contributor.authorTang, Shouchun (Terry)
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorRoussel, Marc R.
dc.date.accessioned2011-12-07T21:39:47Z
dc.date.available2011-12-07T21:39:47Z
dc.date.issued2010
dc.degree.disciplineChemistry & Biochemistry
dc.degree.fieldArts and Sciences
dc.degree.levelDoctor of Philosophy
dc.degree.levelPhD
dc.degree.subfieldSciences
dc.descriptionxi, 102 leaves ; 28 cmen_US
dc.description.abstractUsing the Gillespie algorithm, the export of the mRNA molecules from their transcription site to the nuclear pore complex is simulated. The effect of various structures in the nu- cleus on the efficiency of export is discussed. The results show that having some of the space filled by chromatin near the mRNA synthesis site shortens the transport time. Next, the complete eukaryotic gene expression including transcription, splicing, mRNA export, translation, and mRNA degradation is modeled using delay stochastic simulation. This allows for the study of stochastic effects during the process and on the protein production rate patterns. Various protein production patterns can be produced by adjusting the poly-A tail length of the mRNA and the promoter efficiency of the gene. After that, the opposing effects of the chromatin density on the seeking time of the transcription factors for the promoter and the exit time of the mRNA product are discussed.en_US
dc.identifier.urihttps://hdl.handle.net/10133/2567
dc.language.isoen_USen_US
dc.librarysymbolALU
dc.organizationUniversity of Lethbridge
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Chemistry and Biochemistry, 2010en_US
dc.publisher.departmentDepartment of Chemistry and Biochemistryen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectMessenger RNA -- Researchen_US
dc.subjectProteins -- Synthesisen_US
dc.subjectEukaryotic cells -- Researchen_US
dc.subjectGene expressionen_US
dc.subjectChromatinen_US
dc.subjectCytology -- Mathematical modelsen_US
dc.subjectDissertations, Academicen_US
dc.titleMathematical modeling of eukaryotic gene expressionen_US
dc.typeThesisen_US
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