The bystander effect : animal and plant models

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dc.contributor.authorZemp, Franz Joseph
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorKovalchuk, Igor
dc.contributor.supervisorKovalchuk, Olga
dc.date.accessioned2008-10-27T17:39:47Z
dc.date.available2008-10-27T17:39:47Z
dc.date.issued2008
dc.degree.levelMasters
dc.descriptionxiv, 141 p. : ill. ; 29 cm.en
dc.description.abstractBystander effects are traditionally known as a phenomenon whereby unexposed cells exhibit the molecular symptoms of stress exposure when adjacent or nearby cells are traversed by ionizing radiation. However, the realm of bystander effects can be expanded to include any systemic changes to cellular homeostasis in response to a number of biotic or abiotic stresses, in any molecular system. This thesis encompasses three independent experiments looking at bystander and bystander-like responses in both plant and animal models. In plants, an investigation into the regulation of small RNAs has given us some insights into the regulation of the plant hormone auxin in both stress-treated and systemic (bystander) leaves. Another plant model shows that a bystander-like plant-plant signal can be induced upon ionizing radiation to increase the genome instability of neighbouring unexposed (bystander) plants. In animals, it is shown that the microRNAome is largely affected in the bystander cells in a three-dimensional human tissue model. In silico and bioinfomatic analysis of this data provide us with clues as to the nature of bystander signalling in this human ‘in vivo’ model.en
dc.identifier.urihttps://hdl.handle.net/10133/685
dc.language.isoen_USen
dc.publisherLethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2008en
dc.publisher.departmentDepartment of Biological Sciencesen
dc.publisher.facultyArts and Scienceen
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en
dc.subjectDissertations, Academicen
dc.subjectCells -- Effect of radiation onen
dc.subjectIonizing radiationen
dc.subjectPlants -- Effect of radiation onen
dc.subjectAnimals -- Effect of radiation onen
dc.subjectRNA -- Effect of radiation onen
dc.titleThe bystander effect : animal and plant modelsen
dc.typeThesisen
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