An exploration of amyloid-β seeding in mouse models of dementia

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dc.contributor.authorLacoursiere, Sean
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorSutherland, Robert J.
dc.contributor.supervisorMohajerani, Majid H.
dc.date.accessioned2022-12-02T18:49:17Z
dc.date.available2022-12-02T18:49:17Z
dc.date.issued2022
dc.degree.levelPh.Den_US
dc.description.abstractAlzheimer’s disease (AD) is characterized by the prion-like propagation of misfolded proteins that appears dependent on the initial accumulation of amyloid-β (Aβ). But the role of Aβ in cognitive impairment is still unclear. To determine the causal role of Aβ in AD, mouse models expressing pathological features of AD were intracerebrally seeded with Aβ. Behavioural and immunohistochemical techniques were used to assess the effects of seeding. Seeding was found to increase Aβ plaque deposition and microgliosis throughout the brain after a brief inoculation period. The effect was dependent on the presence of specific knocked-in genes. Seeding was also found to increase the presence of tau hyperphosphorylation in isolated parts of the brain. Yet, no significant correlation between pathology and memory was found. In summary, large increases in Aβ plaque and microgliosis do not initially cause cognitive impairment. Suggesting other underlying disease processes may be driving cognitive decline in AD.en_US
dc.identifier.urihttps://hdl.handle.net/10133/6387
dc.language.isoen_CAen_US
dc.proquest.subject0317en_US
dc.proquest.subject0307en_US
dc.proquest.subject0384en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. :University of Lethbridge, Dept. of Neuroscienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectNeuroscienceen_US
dc.subjectAlzheimer'sen_US
dc.subjectSeedingen_US
dc.subjectMolecularen_US
dc.subjectBehaviouralen_US
dc.subject.lcshMicroglia
dc.subject.lcshAmyloid beta-protein
dc.subject.lcshAlzheimer's disease--Research
dc.subject.lcshDementia--Research
dc.subject.lcshMice--Diseases--Research
dc.subject.lcshDissertations, Academic
dc.titleAn exploration of amyloid-β seeding in mouse models of dementiaen_US
dc.typeThesisen_US
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