Basic fibroblast growth factor improves physiological, anatomical, and functional outcome from bilateral lesions to motor cortex at postnatal day 10 in the rat

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dc.contributor.authorMonfils, Marie-H.
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorKolb, Bryan
dc.date.accessioned2007-03-26T14:33:22Z
dc.date.available2007-03-26T14:33:22Z
dc.date.issued2005
dc.degree.disciplineNeuroscience
dc.degree.fieldArts and Science
dc.degree.levelDoctor of Philosophy
dc.degree.levelPhD
dc.degree.subfieldSciences
dc.descriptionxiii, 171 p. : ill. ; 28 cm.en
dc.description.abstractBasic fibroblast growth factor (FGF-2) is a trophic molecule involved in a number of functions within the central nervous system (CNS), including a prominent role in the regulation of CNS responses to injury. Prior studies suggest that rats recover differently from injury inflicted to different regions and at different ages throughout development, and that FGF-2 might underlie this phenomenon. This thesis examined whether the functional and structural outcome following bilateral injury to the motor cortex inflicted at postnatal day (P10) could be ameliorated by exogenous administration of a growth factor (FGF-2). Four complimentary studies were conducted that each assessed the role of FGF-2 in mediating recovery from bilateral motor cortex injury inflicted at P10. We found that FGF-2 improves physiological, anatomical, and functional outcome from bilateral lesions to motor cortex at P10.en
dc.identifier.urihttps://hdl.handle.net/10133/16
dc.language.isoen_USen
dc.librarysymbolALU
dc.organizationUniversity of Lethbridge
dc.publisherLethbridge, Alta. : University of Lethbridge, Department of Psychology and Neuroscience, 2005en
dc.publisher.departmentDepartment of Neuroscience
dc.publisher.facultyArts and Science
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en
dc.subjectFibroblast growth factorsen
dc.subjectBrain -- Wounds and injuriesen
dc.subjectRats as laboratory animalsen
dc.subjectPhysiology, Experimentalen
dc.subjectDissertations, Academicen
dc.titleBasic fibroblast growth factor improves physiological, anatomical, and functional outcome from bilateral lesions to motor cortex at postnatal day 10 in the raten
dc.typeThesisen
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