Sound processing in the mouse auditory and dorsal neocortices

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dc.contributor.authorAfrashteh, Navvab
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorMohajerani, Majid H.
dc.contributor.supervisorMcNaughton, Bruce L.
dc.date.accessioned2023-04-26T20:44:30Z
dc.date.available2023-04-26T20:44:30Z
dc.date.issued2023
dc.degree.levelPh.Den_US
dc.description.abstractThere are two theories of how the neocortex processes sound. The feature detection theory posits that cortical neurons process sound to extract its features, whereas, in the decoding theory, cortical neurons are viewed as the decoders of “sound objects”: specific spectrotemporal patterns. In this thesis, I assess both theories in a set of longitudinal experiments with simple and complex sounds presented to awake and isoflurane-anesthetized mice. For the feature detection theory, the auditory cortex (AC) maps of tone frequency and frequency modulation (FM) rate are updated. In these maps, new areas and topographic gradients are discovered. The maps are stable across a recording period and reproducible between brain states. Moreover, a region in the primary AC encodes for the FM direction, crucial in the perception of complex sounds. Finally, fast FM rate topographic areas are the most involved in processing MVocs. For the prediction theory, both AC and the dorsal neocortex (DC) were considered. First, network analysis revealed that AC and DC work together to process sounds, with the interaction level determined by acoustic complexity and brain state. Second, a classification analysis showed that both cortices are informative of the stimuli, with AC twice as informative as DC. Isoflurane-anesthesia maintains the informative power of AC but vanishes the power of DC, except for simple sounds. Lastly, a regression analysis between sounds and behavior (predictors) and the cortical activity (response) was performed to assess the power of stimuli to explain the cortical activity. The sound stimuli could explain AC and DC activity up to 68% and 32%, respectively. The higher explanation power of sound is observed for more complex sounds in the awake state. To conclude, despite the simplicity of the feature detection theory, the detection theory provides a superior understanding of the neocortical functions in auditory processing.en_US
dc.description.sponsorshipNSERC CREATE BIP Programen_US
dc.identifier.urihttps://hdl.handle.net/10133/6471
dc.language.isoen_USen_US
dc.proquest.subject0317
dc.proquest.subject0719
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)
dc.subjectanesthesiaen_US
dc.subjectauditory objecten_US
dc.subjectauditory systemen_US
dc.subjectawakeen_US
dc.subjectbrain stateen_US
dc.subjectcalcium imagingen_US
dc.subjectcortexen_US
dc.subjectcortical activity estimationen_US
dc.subjectcortical streams theoryen_US
dc.subjectevoked cortical activityen_US
dc.subjectfeature mapen_US
dc.subjectfrequency modulationsen_US
dc.subjectfunctional characterizationen_US
dc.subjectfunctional connectivityen_US
dc.subjectfunctional mapen_US
dc.subjectGCaMPen_US
dc.subjectmesoscaleen_US
dc.subjectmouseen_US
dc.subjectneuroscienceen_US
dc.subjectobject theoryen_US
dc.subjectoptical imagingen_US
dc.subjectresponse modelingen_US
dc.subjectsensory processingen_US
dc.subjectsound classificationen_US
dc.subjectsound decoding theoryen_US
dc.subjectsound processingen_US
dc.subjectSpatiotemporal structureen_US
dc.subjectstimulus complexityen_US
dc.subjecttonotopyen_US
dc.subjectvocalizationen_US
dc.subjectwidefielden_US
dc.subjectrodentsen_US
dc.subjecthearingen_US
dc.subjectcomputational neuroscienceen_US
dc.subjectsystems neuroscienceen_US
dc.subjectspectrotemporalen_US
dc.subjectacoustic featureen_US
dc.subjectsensory perceptionen_US
dc.subjectMice--Nervous system--Research
dc.subjectNeocortex--Research
dc.subjectAuditory cortex--Research
dc.subjectAuditory pathways--Research
dc.subjectAuditory perception--Research
dc.subjectBrain--Research
dc.subjectNeurosciences
dc.subjectMice as laboratory animals
dc.subjectDissertations, Academic
dc.titleSound processing in the mouse auditory and dorsal neocorticesen_US
dc.typeThesisen_US
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