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dc.contributor.supervisor Sutherland, Robert J.
dc.contributor.author McHugh, Rebecca R.
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2022-07-29T20:46:09Z
dc.date.available 2022-07-29T20:46:09Z
dc.date.issued 2022
dc.identifier.uri https://hdl.handle.net/10133/6301
dc.description.abstract The hippocampus is important for the acquisition, storage, and retrieval of memories. It has been largely examined for its role in spatial and contextual memory, but the mechanisms of encoding temporal cues are not well understood. The present work explores the expression of an immediate early gene which contributes to synaptic changes associated with long-term plasticity, Arc, as a temporally-specific marker of hippocampal memory to a time-of-day cue in a novel conditioning procedure in rats. We video-recorded locomotor activity and delivered a clock time-specific, multimodal alarm signal to cage-paired rats for 14 days, and quantified Arc mRNA expression at conditioned and unconditioned times. We predicted that neural activity associated with a temporally-conditioned response to a time-of-day cue would include expression of Arc genes in the hippocampus and interactions with circadian cycles of sleep-wake behaviour. en_US
dc.language.iso en_CA en_US
dc.publisher Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience en_US
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en_US
dc.subject Natural sciences en_US
dc.subject Hippocampal memory
dc.subject Arc genes
dc.subject.lcsh Hippocampus (Brain)
dc.subject.lcsh Memory--Research
dc.subject.lcsh Long-term memory
dc.subject.lcsh Dissertations, Academic
dc.title Conditioned Arc expression in CA1 of the rat hippocampus supports long-term memory for temporal events en_US
dc.type Thesis en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Neuroscience en_US
dc.degree.level Masters en_US
dc.proquest.subject 0602 en_US
dc.proquest.subject 0317 en_US
dc.proquestyes Yes en_US


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