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dc.contributor.supervisor Sutherland, Robert J.
dc.contributor.author Fomina, Asnate Marianna
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2020-04-30T22:24:37Z
dc.date.available 2020-04-30T22:24:37Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/10133/5713
dc.description.abstract Alzheimer’s disease (AD) starts with toxic changes in the brain disrupting healthy processes and leading to loss of neurons. Dietary sugar can adversely affect health by contributing to inflammation in the body and in the brain (Beilharz, Maniam & Morris, 2015). AD has been referred to as Type 3 diabetes because of the insulin resistance developed in the brain (Kim & Feldman, 2015; Steen et al., 2005; de la Monte, 2009). Conversely, metformin demonstrates beneficial effects, such as anti-inflammatory, increased neurogenesis, enhanced cognition and extended life expectancy (Wang et al., 2012; Saisho, 2015; Martin-Montalvo, et al., 2013). The theory of current study is that disrupted sugar metabolism can create insulin resistance and exacerbate AD pathology. It is hypothesized that high dietary sugar may aggravate AD pathology, while metformin could ameliorate AD. Histology results indicated that sugar increased plaque deposition and inflammation in the brain, while sugar with metformin decreased it. en_US
dc.description.sponsorship Alzheimer's Society of Alberta and Northwest Territories en_US
dc.language.iso en_US en_US
dc.publisher Lethbridge, Alta. : University of Lethbridge, Department of Neuroscience en_US
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en_US
dc.subject Alzheimer's disease en_US
dc.subject sugar en_US
dc.subject metformin en_US
dc.subject rodents en_US
dc.subject Alzheimer's disease -- Research en_US
dc.subject Alzheimer's disease -- Chemotherapy en_US
dc.subject Alzheimer's disease -- Animal models en_US
dc.subject Sugar -- Health aspects en_US
dc.subject Metformin -- Therapeutic use en_US
dc.subject Inflammation en_US
dc.subject Mice as laboratory animals en_US
dc.subject Dissertations, Academic en_US
dc.title Effect of high dietary sugar and metformin in a mouse model of Alzheimer's disease en_US
dc.type Thesis en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Neuroscience en_US
dc.degree.level Masters en_US
dc.proquest.subject 0317 en_US
dc.proquest.subject 0570 en_US
dc.proquest.subject 0493 en_US
dc.proquestyes Yes en_US


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