Effect of high dietary sugar and metformin in a mouse model of Alzheimer's disease

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dc.contributor.authorFomina, Asnate Marianna
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorSutherland, Robert J.
dc.date.accessioned2020-04-30T22:24:37Z
dc.date.available2020-04-30T22:24:37Z
dc.date.issued2020
dc.degree.levelMastersen_US
dc.description.abstractAlzheimer’s disease (AD) starts with toxic changes in the brain disrupting healthy processes and leading to loss of neurons. Dietary sugar can adversely affect health by contributing to inflammation in the body and in the brain (Beilharz, Maniam & Morris, 2015). AD has been referred to as Type 3 diabetes because of the insulin resistance developed in the brain (Kim & Feldman, 2015; Steen et al., 2005; de la Monte, 2009). Conversely, metformin demonstrates beneficial effects, such as anti-inflammatory, increased neurogenesis, enhanced cognition and extended life expectancy (Wang et al., 2012; Saisho, 2015; Martin-Montalvo, et al., 2013). The theory of current study is that disrupted sugar metabolism can create insulin resistance and exacerbate AD pathology. It is hypothesized that high dietary sugar may aggravate AD pathology, while metformin could ameliorate AD. Histology results indicated that sugar increased plaque deposition and inflammation in the brain, while sugar with metformin decreased it.en_US
dc.description.sponsorshipAlzheimer's Society of Alberta and Northwest Territoriesen_US
dc.identifier.urihttps://hdl.handle.net/10133/5713
dc.language.isoen_USen_US
dc.proquest.subject0317en_US
dc.proquest.subject0570en_US
dc.proquest.subject0493en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Department of Neuroscienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectsugaren_US
dc.subjectmetforminen_US
dc.subjectrodentsen_US
dc.subjectAlzheimer's disease -- Researchen_US
dc.subjectAlzheimer's disease -- Chemotherapyen_US
dc.subjectAlzheimer's disease -- Animal modelsen_US
dc.subjectSugar -- Health aspectsen_US
dc.subjectMetformin -- Therapeutic useen_US
dc.subjectInflammationen_US
dc.subjectMice as laboratory animalsen_US
dc.subjectDissertations, Academicen_US
dc.titleEffect of high dietary sugar and metformin in a mouse model of Alzheimer's diseaseen_US
dc.typeThesisen_US
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