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dc.contributor.supervisor Vos, Ken
dc.contributor.author Osunbiyi, Olusoji
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2020-04-20T20:39:03Z
dc.date.available 2020-04-20T20:39:03Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/10133/5708
dc.description.abstract 5-Fluorouracil (5-FU) is extensively biotransformed to dihydrofluorouracil (DHFU) by the dihydropyrimidine dehydrogenase enzyme (DPD) that catalyzes the reduction of uracil and thymine. This research involves the development of intensive quantitative compartment models that predict the time course of 5-FU and DHFU in the body using the Runge-Kutta fourth order method. The parameters within our system of nonlinear differential equations were determined by fitting the models to the clinical data. We showed that the one-compartment model was insufficient to describe the kinetics of 5-FU and that a minimum of two compartments is needed. The area under the curve (AUC), maximum concentration ($C_{max}$), and half-life ($t_{1/2}$) were obtained from the theoretical solutions to our models. Further work was done on how age and gender influence the drug's interaction with the body. It was determined that age reduces the rate of elimination and women are more prone to toxic effects. en_US
dc.language.iso en_US en_US
dc.publisher Lethbridge, Alta. : University of Lethbridge, Dept. of Physics and Astronomy en_US
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en_US
dc.subject Pharmacokinetics en_US
dc.subject Pharmacology en_US
dc.subject Chemotherapy en_US
dc.subject Cancer -- Chemotherapy en_US
dc.subject Pharmacokinetics -- Mathematical models en_US
dc.subject Cancer -- Treatment en_US
dc.title A multi-compartment pharmacokinetic model of 5-fluorouracil and dihydrofluorouracil en_US
dc.type Thesis en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Physics and Astronomy en_US
dc.degree.level Masters en_US
dc.proquestyes No en_US


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