A multi-compartment pharmacokinetic model of 5-fluorouracil and dihydrofluorouracil

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dc.contributor.authorOsunbiyi, Olusoji
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorVos, Ken
dc.date.accessioned2020-04-20T20:39:03Z
dc.date.available2020-04-20T20:39:03Z
dc.date.issued2020
dc.degree.levelMastersen_US
dc.description.abstract5-Fluorouracil (5-FU) is extensively biotransformed to dihydrofluorouracil (DHFU) by the dihydropyrimidine dehydrogenase enzyme (DPD) that catalyzes the reduction of uracil and thymine. This research involves the development of intensive quantitative compartment models that predict the time course of 5-FU and DHFU in the body using the Runge-Kutta fourth order method. The parameters within our system of nonlinear differential equations were determined by fitting the models to the clinical data. We showed that the one-compartment model was insufficient to describe the kinetics of 5-FU and that a minimum of two compartments is needed. The area under the curve (AUC), maximum concentration ($C_{max}$), and half-life ($t_{1/2}$) were obtained from the theoretical solutions to our models. Further work was done on how age and gender influence the drug's interaction with the body. It was determined that age reduces the rate of elimination and women are more prone to toxic effects.en_US
dc.identifier.urihttps://hdl.handle.net/10133/5708
dc.language.isoen_USen_US
dc.proquestyesNoen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Physics and Astronomyen_US
dc.publisher.departmentDepartment of Physics and Astronomyen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectPharmacokineticsen_US
dc.subjectPharmacologyen_US
dc.subjectChemotherapyen_US
dc.subjectCancer -- Chemotherapyen_US
dc.subjectPharmacokinetics -- Mathematical modelsen_US
dc.subjectCancer -- Treatmenten_US
dc.titleA multi-compartment pharmacokinetic model of 5-fluorouracil and dihydrofluorouracilen_US
dc.typeThesisen_US
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