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dc.contributor.supervisor Metz, Gerlinde A. S.
dc.contributor.supervisor Montina, Tony
dc.contributor.author Poplawski, Janet
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2019-09-06T16:35:32Z
dc.date.available 2019-09-06T16:35:32Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/10133/5552
dc.description.abstract Stress is one of the most critical determinants of lifetime health. To gain insight into the underlying gene-environment interactions governing the effects of stress on development and behaviour, we (i) utilized proton nuclear magnetic spectroscopy to analyze cardiorenal and cerebral metabolomes of animals exposed to a multidimensional early-life stressor, and (ii) used immunohistochemical, transcriptomic, and behavioural analyses to examine the impacts of multidimensional early-life stress on offspring anxiety-like behaviours and visual development. Metabolomic profiles revealed significant changes as a result of early postnatal stress. Dysregulation of energy and protein metabolism suggests an increased risk of metabolic diseases like insulin resistance, cardiorenal syndrome, diabetes, obesity, and mental health disorders. Additionally, multidimensional early-life stress accelerated the functional and cellular development of the visual system. These findings provide novel insights into the effects of early-life stress on metabolism, development, and behaviour by combining behavioural, histological, metabolomic, and transcriptomic approaches in a rodent model. en_US
dc.language.iso en_US en_US
dc.publisher Lethbridge, Alta. : Universtiy of Lethbridge, Department of Neuroscience en_US
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en_US
dc.subject adverse health en_US
dc.subject developmental neuroscience en_US
dc.subject early postnatal stress en_US
dc.subject metabolomics en_US
dc.subject trauma en_US
dc.subject Dissertations, Academic en_US
dc.title Multidimensional early postnatal stress permanently programs metabolism, development, and behaviour: linking trauma to adverse health outcomes en_US
dc.type Thesis en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Neuroscience en_US
dc.degree.level Masters en_US
dc.proquest.subject 0758 en_US
dc.proquest.subject 0317 en_US
dc.proquest.subject 0423 en_US
dc.proquestyes Yes en_US


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