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dc.contributor.supervisor McNaughton, Bruce L.
dc.contributor.author McKinnon, Jarret
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2019-06-19T16:39:55Z
dc.date.available 2019-06-19T16:39:55Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/10133/5407
dc.description.abstract Environmental enrichment (EE) upregulates neurotrophin (NT) expression in both the hippocampus (HPC) and neocortex. We expected this effect to be reduced in the NC by hippocampal lesions. To test this, middle-aged female rats with unilateral, bilateral or sham lesions of the HPC, lived in enriched or social housing. After three months, rats freely explored a novel environment for 5 minutes, were immediately perfused and brains processed for brain derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) protein. Hippocampal lesions had no effect on BDNF in neocortex. Right, but not left, hippocampal lesions had a significant negative impact on behavioral exploration of social rats; and this effect was not present in the enriched group. Enriched rats showed significantly reduced BDNF expression in deep cortex with a similar trend in superficial layers regardless of lesion condition. The role of the HPC in neocortical plasticity processes remains variable and unclear. en_US
dc.description.sponsorship AIHS Polaris Award en_US
dc.language.iso en_US en_US
dc.publisher Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience en_US
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science)
dc.subject Brain derived neurotrophic factor en_US
dc.subject Environmental enrichment en_US
dc.subject Hippocampus en_US
dc.subject Neurotrophin en_US
dc.subject Rats en_US
dc.title The Effects of Hippocampal Lesions on Neurotrophins in the Rodent Neocortex en_US
dc.type Thesis en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Neuroscience en_US
dc.degree.level Masters en_US
dc.proquest.subject Neurosciences [0317] en_US
dc.proquest.subject Psychobiology [0349] en_US
dc.proquest.subject Physiological psychology [0989] en_US
dc.proquestyes Yes en_US
dc.embargo No en_US


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