The Effects of Hippocampal Lesions on Neurotrophins in the Rodent Neocortex

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dc.contributor.authorMcKinnon, Jarret
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorMcNaughton, Bruce L.
dc.date.accessioned2019-06-19T16:39:55Z
dc.date.available2019-06-19T16:39:55Z
dc.date.issued2019
dc.degree.levelMastersen_US
dc.description.abstractEnvironmental enrichment (EE) upregulates neurotrophin (NT) expression in both the hippocampus (HPC) and neocortex. We expected this effect to be reduced in the NC by hippocampal lesions. To test this, middle-aged female rats with unilateral, bilateral or sham lesions of the HPC, lived in enriched or social housing. After three months, rats freely explored a novel environment for 5 minutes, were immediately perfused and brains processed for brain derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) protein. Hippocampal lesions had no effect on BDNF in neocortex. Right, but not left, hippocampal lesions had a significant negative impact on behavioral exploration of social rats; and this effect was not present in the enriched group. Enriched rats showed significantly reduced BDNF expression in deep cortex with a similar trend in superficial layers regardless of lesion condition. The role of the HPC in neocortical plasticity processes remains variable and unclear.en_US
dc.description.sponsorshipAIHS Polaris Awarden_US
dc.embargoNoen_US
dc.identifier.urihttps://hdl.handle.net/10133/5407
dc.language.isoen_USen_US
dc.proquest.subjectNeurosciences [0317]en_US
dc.proquest.subjectPsychobiology [0349]en_US
dc.proquest.subjectPhysiological psychology [0989]en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Neuroscienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)
dc.subjectBrain derived neurotrophic factoren_US
dc.subjectEnvironmental enrichmenten_US
dc.subjectHippocampusen_US
dc.subjectNeurotrophinen_US
dc.subjectRatsen_US
dc.titleThe Effects of Hippocampal Lesions on Neurotrophins in the Rodent Neocortexen_US
dc.typeThesisen_US
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