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dc.contributor.author Marszaukowskia, Flávia
dc.contributor.author Guimarãesa, Ivelise Dimbarre Lao
dc.contributor.author da Silvaa, Juliana Paula
dc.contributor.author da Silveira Lacerda, Luis Henrique
dc.contributor.author de Lazaroa, Sergio Ricardo
dc.contributor.author de Araujob, Márcio Peres
dc.contributor.author Castellena, Patrícia
dc.contributor.author Tominaga, Tania Toyomi
dc.contributor.author Boeré, René T.
dc.contributor.author Wohnrath, Karen
dc.date.accessioned 2019-05-13T19:02:42Z
dc.date.available 2019-05-13T19:02:42Z
dc.date.issued 2019
dc.identifier.citation Marszaukowskia, F., Guimarães, I. D. L., da Silva, J. P., da Silveira Lacerda, L. H., de Lazaro, S. R., de Araujo, M. P.,...Wohnrath, K. (2019). Ruthenium(II)-arene complexes with monodentate aminopyridine ligands: Insights into redox stability, electronic structures and biological activity. Journal of Organometallic Chemistry, 881, 66-78. DOI: 10.1016/j.jorganchem.2018.11.036 en_US
dc.identifier.uri https://hdl.handle.net/10133/5355
dc.description Sherpa Romeo green journal. Permission to archive accepted author manuscript. en_US
dc.description.abstract The synthesis and spectroscopic characterization of four ruthenium(II) arene complexes with monodentate pyridine derivatives ([( 6–p-cymene)RuCl2L]: L = 2-aminopyridine, 2-methylaminopyridine, 2-benzylaminopyridine, and pyridine) are reported. Full characterization was undertaken using 1H and 13C NMR spectroscopy, vibrational and electronic spectroscopies and crystallography (2-methylaminopyridine derivative). UB3LYP//(6-31+G(d),SPK-DZCD) density functional theory calculations determined the molecular and electronic structures. Cyclic voltammetry determined a large electrochemical stability window (>2.2 V) extending well beyond the physiological E°. Interactions with CT-DNA and BSA, and activity against four cell lines (HeLa, B16F10, HEp-2 and Vero) were evaluated. The 2-methylaminopyridine shows weak cytotoxicity (IC50 = 346 molL-1) towards HeLa cells. All the complexes interact with DNA at relatively high concentrations as determined by UV-vis spectroscopic titration. Results of circular dichroism spectroscopy, ethidium bromide competition, fluorescence spectroscopy and DNA viscosity measurements identify electrostatic interactions between partly hydrolyzed cationic complexes and the phosphate backbone of DNA as the most likely interaction mode. Slower rates of hydrolysis may be the origin of lower cytotoxicity for 1 these complexes en_US
dc.language.iso en_US en_US
dc.publisher Elsevier en_US
dc.subject Ruthenium(II)-arene en_US
dc.subject Pyridine ligands en_US
dc.subject DNA interaction en_US
dc.subject BSA interaction en_US
dc.subject Cytotoxicity en_US
dc.subject Crystal structure en_US
dc.title Ruthenium(II)-arene complexes with monodentate aminopyridine ligands: insights into redox stability, electronic structures and biological activity en_US
dc.type Article en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Chemistry and Biochemistry en_US
dc.description.peer-review Yes en_US
dc.publisher.institution Universidade Estadual de Ponta Grossa en_US
dc.publisher.institution Universidade Federal do Paraná en_US
dc.publisher.institution Universidade Estadual do Centro-Oeste en_US
dc.publisher.institution University of Lethbridge en_US
dc.publisher.url https://doi.org/10.1016/j.jorganchem.2018.11.036


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