Ruthenium(II)-arene complexes with monodentate aminopyridine ligands: insights into redox stability, electronic structures and biological activity

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dc.contributor.authorMarszaukowskia, Flávia
dc.contributor.authorGuimarãesa, Ivelise Dimbarre Lao
dc.contributor.authorda Silvaa, Juliana Paula
dc.contributor.authorda Silveira Lacerda, Luis Henrique
dc.contributor.authorde Lazaroa, Sergio Ricardo
dc.contributor.authorde Araujob, Márcio Peres
dc.contributor.authorCastellena, Patrícia
dc.contributor.authorTominaga, Tania Toyomi
dc.contributor.authorBoeré, René T.
dc.contributor.authorWohnrath, Karen
dc.date.accessioned2019-05-13T19:02:42Z
dc.date.available2019-05-13T19:02:42Z
dc.date.issued2019
dc.descriptionSherpa Romeo green journal. Permission to archive accepted author manuscript.en_US
dc.description.abstractThe synthesis and spectroscopic characterization of four ruthenium(II) arene complexes with monodentate pyridine derivatives ([( 6–p-cymene)RuCl2L]: L = 2-aminopyridine, 2-methylaminopyridine, 2-benzylaminopyridine, and pyridine) are reported. Full characterization was undertaken using 1H and 13C NMR spectroscopy, vibrational and electronic spectroscopies and crystallography (2-methylaminopyridine derivative). UB3LYP//(6-31+G(d),SPK-DZCD) density functional theory calculations determined the molecular and electronic structures. Cyclic voltammetry determined a large electrochemical stability window (>2.2 V) extending well beyond the physiological E°. Interactions with CT-DNA and BSA, and activity against four cell lines (HeLa, B16F10, HEp-2 and Vero) were evaluated. The 2-methylaminopyridine shows weak cytotoxicity (IC50 = 346 molL-1) towards HeLa cells. All the complexes interact with DNA at relatively high concentrations as determined by UV-vis spectroscopic titration. Results of circular dichroism spectroscopy, ethidium bromide competition, fluorescence spectroscopy and DNA viscosity measurements identify electrostatic interactions between partly hydrolyzed cationic complexes and the phosphate backbone of DNA as the most likely interaction mode. Slower rates of hydrolysis may be the origin of lower cytotoxicity for 1 these complexesen_US
dc.description.peer-reviewYesen_US
dc.identifier.citationMarszaukowskia, F., Guimarães, I. D. L., da Silva, J. P., da Silveira Lacerda, L. H., de Lazaro, S. R., de Araujo, M. P.,...Wohnrath, K. (2019). Ruthenium(II)-arene complexes with monodentate aminopyridine ligands: Insights into redox stability, electronic structures and biological activity. Journal of Organometallic Chemistry, 881, 66-78. DOI: 10.1016/j.jorganchem.2018.11.036en_US
dc.identifier.urihttps://hdl.handle.net/10133/5355
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.publisher.departmentDepartment of Chemistry and Biochemistryen_US
dc.publisher.facultyArts and Scienceen_US
dc.publisher.institutionUniversidade Estadual de Ponta Grossaen_US
dc.publisher.institutionUniversidade Federal do Paranáen_US
dc.publisher.institutionUniversidade Estadual do Centro-Oesteen_US
dc.publisher.institutionUniversity of Lethbridgeen_US
dc.publisher.urlhttps://doi.org/10.1016/j.jorganchem.2018.11.036
dc.subjectRuthenium(II)-areneen_US
dc.subjectPyridine ligandsen_US
dc.subjectDNA interactionen_US
dc.subjectBSA interactionen_US
dc.subjectCytotoxicityen_US
dc.subjectCrystal structureen_US
dc.titleRuthenium(II)-arene complexes with monodentate aminopyridine ligands: insights into redox stability, electronic structures and biological activityen_US
dc.typeArticleen_US
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