Show simple item record Thome, Alexander Marrone, Diano F. Ellmore, Timothy M. Chawla, Monica K. Lipa, Peter Ramirez-Amaya, Victor Lisanby, Sarah H. McNaughton, Bruce L. Barnes, Carol A. 2019-04-23T21:20:16Z 2019-04-23T21:20:16Z 2017
dc.identifier.citation Thome, A., Marrone, D. F., Ellmore, T. M., Chawla, M. K., Lipa, P., Ramirez-Amaya, V.,...Barnes, C. A. (2017). Evidence for an evolutionary conserved memory coding scheme in the mammalian hippocampus. Journal of Neuroscience, 37(10), 2795-2801. DOI:10.1523/JNEUROSCI.3057-16.2017 en_US
dc.description Sherpa Romeo yellow journal. Open access article. Creative Commons Attribution 4.0 International License (CC BY 4.0) applies en_US
dc.description.abstract Decades of research identify the hippocampal formation as central to memory storage and recall. Events are stored via distributed population codes, the parameters of which (e.g., sparsity and overlap) determine both storage capacity and fidelity. However, it remains unclear whether the parameters governing information storage are similar between species. Because episodic memories are rooted in the space in which they are experienced, the hippocampal response to navigation is often used as a proxy to study memory. Critically, recent studies in rodents that mimic the conditions typical of navigation studies in humans and non human primates (i.e.,virtual reality) show that reduced sensory input alters hippocampal representations of space. The goal of this study was to quantify this effect and determine whether there are commonalities in information storage across species. Using functional molecular imaging, we observe that navigation in virtual environments elicits activity in fewer CA1 neurons relative to real-world conditions. Conversely, comparable neuronal activity is observed in hippocampus region CA3 and the dentate gyrus under both conditions. Surprisingly, we also find evidence that the absolute number of neurons used to represent an experience is relatively stable between non human primates and rodents. We propose that this convergence reflects an optimal ensemble size for episodic memories. en_US
dc.language.iso en_US en_US
dc.publisher Society for Neuroscience en_US
dc.subject Neural coding en_US
dc.subject Neuroethology en_US
dc.subject Primate en_US
dc.subject Rodent en_US
dc.subject Spatial cognition en_US
dc.subject Virtual reality en_US
dc.subject CA3
dc.subject CA1
dc.subject.lcsh Memory--Research
dc.subject.lcsh Episodic memory
dc.subject.lcsh Hippocampus (Brain)
dc.subject.lcsh Rats as laboratory animals
dc.title Evidence for an evolutionary conserved memory coding scheme in the mammalian hippocampus en_US
dc.type Article en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Neuroscience en_US
dc.description.peer-review Yes en_US
dc.publisher.institution Evelyn F. McKnight Brain Institute en_US
dc.publisher.institution University of Arizona en_US
dc.publisher.institution Wilfrid Laurier University en_US
dc.publisher.institution City College of New York en_US
dc.publisher.institution Universidad Autónoma de Queretaro en_US
dc.publisher.institution Instituto deI nvestigación Médica Mercedes y Martín Ferreyra en_US
dc.publisher.institution Duke University en_US
dc.publisher.institution University of Lethbridge en_US
dc.publisher.institution University of California en_US

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