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dc.contributor.author Costa, Estela
dc.contributor.author Uwiera, Richard R. E.
dc.contributor.author Kastelic, John P.
dc.contributor.author Selinger, L. Brent
dc.contributor.author Inglis, G. Douglas
dc.date.accessioned 2017-07-11T23:07:48Z
dc.date.available 2017-07-11T23:07:48Z
dc.date.issued 2011
dc.identifier.citation Costa, E., Uwiera, R.R.E., Kastelic, J.P., Selinger, L.B., & Inglis, G.D. (2011). Non-therapeutic adminstration of a model antimicrobial growth promoter modulates intestinal immune responses. Gut Pathogens, 3(14).doi:10.1186/1757-4749-3-14: en_US
dc.identifier.uri https://hdl.handle.net/10133/4858
dc.description Sherpa Romeo green journal: open access en_US
dc.description.abstract Background: The development of efficacious alternatives to antimicrobial growth promoters (AGP) in livestock production is an urgent issue, but is hampered by a lack of knowledge regarding the mode of action of AGP. The belief that AGP modulate the intestinal microbiota has become prominent in the literature; however, there is a lack of experimental evidence to support this hypothesis. Using a chlortetracycline-murine-Citrobacter rodentium model, the ability of AGP to modulate the intestinal immune system in mammals was investigated. Results: C. rodentium was transformed with the tetracycline resistance gene, tetO, and continuous oral administration of a non-therapeutic dose of chlortetracycline to mice did not affect densities of C. rodentium CFU in feces throughout the experiment or associated with mucosal surfaces in the colon (i.e. at peak and late infection). However, chlortetracycline regulated transcription levels of Th1 and Th17 inflammatory cytokines in a temporal manner in C. rodentium-inoculated mice, and ameliorated weight loss associated with infection. In mice inoculated with C. rodentium, those that received chlortetracycline had less pathologic changes in the distal colon than mice not administered CTC (i.e. relative to untreated mice). Furthermore, chlortetracycline administration at a non-therapeutic dose did not impart either prominent or consistent effects on the colonic microbiota. Conclusion: Data support the hypothesis that AGP function by modulating the intestinal immune system in mammals. This finding may facilitate the development of biorationale-based and efficacious alternatives to AGP. en_US
dc.language.iso en_US en_US
dc.publisher BioMed Central en_US
dc.subject Antimicrobial growth promoters en_US
dc.subject AGP en_US
dc.subject Chlortetracycline en_US
dc.subject Citrobacter rodentium en_US
dc.subject Immunomodulation hypothesis en_US
dc.title Non-therapeutic administration of a model antimicrobial growth promoter modulates intestinal immune responses en_US
dc.type Article en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Biological Sciences en_US
dc.description.peer-review Yes en_US
dc.publisher.institution Lethbridge Research Centre en_US
dc.publisher.institution University of Lethbridge en_US
dc.publisher.institution University of Alberta en_US


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