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dc.contributor.supervisor Hontela, Alice
dc.contributor.supervisor Pyle, Gregory
dc.contributor.author Keller, Antonio Goes Ferreira dos Santos
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2017-06-01T21:30:53Z
dc.date.available 2017-06-01T21:30:53Z
dc.date.issued 2017
dc.identifier.uri https://hdl.handle.net/10133/4853
dc.description.abstract The effects of climate change, hypoxia of surface waters, disposal of pharmaceuticals, among other stressors to freshwater ecosystems, are important concerns of modern civilization. Diltiazem (DTZ) is a calcium channel blocker prescribed for heart diseases in humans; however, the knowledge of the effects of DTZ in the aquatic environment is limited. The present study investigated the cardiovascular effects of DTZ in rainbow trout. Fish were exposed in the laboratory to DTZ (0, 1, 10, 100 and 1000μg/L) for 96 hours at different temperatures (4ºC, 10ºC and 18ºC) and different dissolved oxygen concentrations (4mg/L and 8mg/L). DTZ (1 and 10 μg/L) impaired the increase of hemoglobin under hypoxia, at 1 μg/L impaired the increase of the ventilation rate, and at 10 μg/L increased the immature RBC counts, suggesting impairment of the cardiovascular system of rainbow trout. No statistically significant effects of DTZ on heart rate, oxygen consumption or hematocrit were detected. en_US
dc.language.iso en_US en_US
dc.publisher Lethbridge, Alta : University of Lethbridge, Dept. of Biological Sciences en_US
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en_US
dc.subject DTZ en_US
dc.subject fish cardiovascular performance en_US
dc.subject hemoglobin synthesis en_US
dc.subject hypoxic conditions en_US
dc.subject multiple stressor environment en_US
dc.subject temperature en_US
dc.title The effects of multiple stressors (diltiazem, hypoxia, and temperature) on the cardiovascular function of rainbow trout en_US
dc.type Thesis en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Biological Sciences en_US
dc.degree.level Masters en_US
dc.proquest.subject 0719 en_US
dc.proquest.subject 0383 en_US
dc.proquest.subject 0768 en_US
dc.proquestyes Yes en_US
dc.embargo No en_US


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