The effects of multiple stressors (diltiazem, hypoxia, and temperature) on the cardiovascular function of rainbow trout

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dc.contributor.authorKeller, Antonio Goes Ferreira dos Santos
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorHontela, Alice
dc.contributor.supervisorPyle, Gregory
dc.date.accessioned2017-06-01T21:30:53Z
dc.date.available2017-06-01T21:30:53Z
dc.date.issued2017
dc.degree.levelMastersen_US
dc.description.abstractThe effects of climate change, hypoxia of surface waters, disposal of pharmaceuticals, among other stressors to freshwater ecosystems, are important concerns of modern civilization. Diltiazem (DTZ) is a calcium channel blocker prescribed for heart diseases in humans; however, the knowledge of the effects of DTZ in the aquatic environment is limited. The present study investigated the cardiovascular effects of DTZ in rainbow trout. Fish were exposed in the laboratory to DTZ (0, 1, 10, 100 and 1000μg/L) for 96 hours at different temperatures (4ºC, 10ºC and 18ºC) and different dissolved oxygen concentrations (4mg/L and 8mg/L). DTZ (1 and 10 μg/L) impaired the increase of hemoglobin under hypoxia, at 1 μg/L impaired the increase of the ventilation rate, and at 10 μg/L increased the immature RBC counts, suggesting impairment of the cardiovascular system of rainbow trout. No statistically significant effects of DTZ on heart rate, oxygen consumption or hematocrit were detected.en_US
dc.embargoNoen_US
dc.identifier.urihttps://hdl.handle.net/10133/4853
dc.language.isoen_USen_US
dc.proquest.subject0719en_US
dc.proquest.subject0383en_US
dc.proquest.subject0768en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta : University of Lethbridge, Dept. of Biological Sciencesen_US
dc.publisher.departmentDepartment of Biological Sciencesen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectDTZen_US
dc.subjectfish cardiovascular performanceen_US
dc.subjecthemoglobin synthesisen_US
dc.subjecthypoxic conditionsen_US
dc.subjectmultiple stressor environmenten_US
dc.subjecttemperatureen_US
dc.titleThe effects of multiple stressors (diltiazem, hypoxia, and temperature) on the cardiovascular function of rainbow trouten_US
dc.typeThesisen_US
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