Neuroscience

 

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  • Whishaw, Ian Q.; Faraji, Jamshid; Kuntz, Jessica R.; Agha, Behroo M.; Metz, Gerlinde A. S.; Mohajerani, Majid H. (Nature ResearchArts and ScienceDepartment of NeuroscienceUniversity of LethbridgeGolestan University of Medical Scienceshttps://doi.org/10.1038/s41598-017-10796-y, 2017)
    Mice are adept in the use of their hands for activities such as feeding, which has led to their use in investigations of the neural basis of skilled-movements. We describe the syntactic organization of pasta-eating and the ...
  • Himmler, Stephanie M.; Lewis, Jena M.; Pellis, Sergio M. (eScholarship Publishing, University of CaliforniaArts and ScienceDepartment of NeuroscienceUniversity of Lethbridgehttps://escholarship.org/uc/item/73k494jm, 2014)
    During play fighting, rats attack and defend the nape, which if contacted is nuzzled with the snout. While all strains of rats use the same suite of defensive tactics to protect the nape, different strains use some tactics ...
  • Himmler, Brett T.; Himmler, Stephanie M.; Stryjek, Rafal; Modlinska, Klaudia; Pisula, Wojciech; Pellis, Sergio M. (eScholarship Publishing, University of CaliforniaArts and ScienceDepartment of NeuroscienceUniversity of LethbridgePolish Academy of Scienceshttps://escholarship.org/uc/item/9wh1h32n, 2015)
    Play fighting in rats involves attack and defense of the nape. To protect the nape, rats use a variety of defensive tactics, with different strains having specific preferences. Targeting of the nape is established before ...
  • Himmler, Stephanie M.; Himmler, Brett T.; Stryjek, Rafal; Modlinska, Klaudia; Pisula, Wojciech; Pellis, Sergio M. (eScholarship Publishing, University of CaliforniaArts and ScienceDepartment of NeuroscienceUniversity of LethbridgePolish Academy of ScienceUniversity of Minnesota Medical Schoolhttps://escholarship.org/uc/item/2jm2z5wc, 2016)
    During play fighting, rats attack and defend the nape of the neck and during the course of this competitive interaction, they may adopt a configuration in which one animal stands over its supine partner (i.e., pin). Because ...
  • Thome, Alexander; Marrone, Diano F.; Ellmore, Timothy M.; Chawla, Monica K.; Lipa, Peter; Ramirez-Amaya, Victor; Lisanby, Sarah H.; McNaughton, Bruce L.; Barnes, Carol A. (Society for NeuroscienceArts and ScienceDepartment of NeuroscienceEvelyn F. McKnight Brain InstituteUniversity of ArizonaWilfrid Laurier UniversityCity College of New YorkUniversidad Autónoma de QueretaroInstituto deI nvestigación Médica Mercedes y Martín FerreyraDuke UniversityUniversity of LethbridgeUniversity of Californiahttps://doi.org/10.1523/JNEUROSCI.3057-16.2017, 2017)
    Decades of research identify the hippocampal formation as central to memory storage and recall. Events are stored via distributed population codes, the parameters of which (e.g., sparsity and overlap) determine both storage ...
  • Wilber, Aaron A.; Clark, Benjamin J.; Forster, Tyler C.; Tatsuno, Masami; McNaughton, Bruce L. (Society for NeuroscienceArts and ScienceDepartment of NeuroscienceUniversity of Lethbridgehttps://doi.org/10.1523/JNEUROSCI.0511-14.2014, 2014)
    Navigation requires coordination of egocentric and allocentric spatial reference frames and may involve vectorial computations relative to landmarks. Creation of are presentation of target heading relative to landmarks ...
  • Schwindel, C. Daniela; Ali, Karim; McNaughton, Bruce L.; Tatsuno, Masami (Society for NeuroscienceArts and ScienceDepartment of NeuroscienceUniversity of Lethbridgehttps://doi.org/10.1523/JNEUROSCI.4350-13.2014, 2014)
    Characterization of synaptic connectivity is essential to understanding neural circuit dynamics. For extracellularly recorded spike trains, indirect evidence for connectivity can be inferred from short-latency peaks in the ...
  • Schwindel, C. Daniela; Navratilova, Zaneta; Ali, Karim; Tatsuno, Masami; McNaughton, Bruce L. (Society for NeuroscienceArts and ScienceDepartment of NeuroscienceUniversity of LethbridgeUniversity of CaliforniaNeuroelectronic Research Flandershttps://doi.org/10.1523/JNEUROSCI.1678-15.2016, 2016)
    The hippocampus is thought to contribute to episodic memory by creating, storing, and reactivating patterns that are unique to each experience, including different experiences that happen at the same location. Hippocampus ...
  • Lehmann, Hugo; Sparks, Fraser T.; Spanswick, Simon C.; Hadikin, Crystal; McDonald, Robert J.; Sutherland, Robert J. (Cold Spring Harbor Laboratory PressArts and ScienceDepartment of NeuroscienceTrent UniversityUniversity of Lethbridgehttps://dx.doi.org/10.1101/lm.1385409, 2009)
    We present evidence that certain learning parameters can make a memory, even a very recent one, become independent of the hippocampus. We confirm earlier findings that damage to the hippocampus causes severe retrograde ...
  • Spanswick, Simon C.; Sutherland, Robert J. (Cold Spring Harbor Laboratory PressArts and ScienceDepartment of NeuroscienceUniversity of Lethbridgehttps://dx.doi.org/10.1101/lm.1746710, 2010)
    Chronic adrenalectomy (ADX) causes a gradual and selective loss of granule cells in the dentate gyrus (DG) of the rat.Here, we administered replacement corticosterone to rats beginning 10wk after ADX. We then tested them ...
  • Spanswick, Simon C.; Lehmann, Hugo; Sutherland, Robert J. (Hindawi PublishingArts and ScienceDepartment of NeuroscienceUniversity of CalgaryTrent UniversityUniversity of Lethbridgehttps://dx.doi.org/10.1155/2011/527201, 2011)
    Long-term adrenalectomy (ADX) results in an extensive and specific loss of dentate gyrus granule cells in the hippocampus of adult rats. This loss of granule cells extends over a period of weeks to months and ultimately ...
  • Kovalchuk, Anna; Ilnytskyy, Yaroslav; Rodriquez-Juarez, Rocio; Katz, Amanda; Sidransky, David; Kolb, Bryan; Kovalchuk, Olga (Impact JournalsArts and ScienceDepartment of Biological SciencesDepartment of NeuroscienceUniversity of LethbridgeChampions OncologyUniversity of Calgaryhttps://dx.doi.org/10.18632/oncotarget.19835, 2017)
    A wide array of central nervous system complications, neurological deficits, and cognitive impairments occur and persist as a result of systemic cancer and cancer treatments. This condition is known as chemo brain and it ...
  • Kovalchuk, Anna; Mychasiuk, Richelle; Muhammad, Arif; Hossain, Shakhawat; Ilnytskyy, Slava; Ghose, Abhijit; Kirby, Charles; Ghasroddashti3, Esmaeel; Kovalchuk, Olga; Kolb, Bryan (Impact JournalsArts and ScienceDepartment of Biological SciencesDepartment of NeuroscienceUniversity of LethbridgeAlberta Health ServicesUniversity of CalgaryAlberta Epigenetics NetworkCanadian Institute for Advanced Researchhttps://doi.org/10.18632/oncotarget.6596, 2016)
    Radiation therapy can not only produce effects on targeted organs, but can also influence shielded bystander organs, such as the brain in targeted liver irradiation. The brain is sensitive to radiation exposure, and ...
  • Wang, Justin; Wu, Chiping; Peng, Jessie; Patel, Nisarg; Huang, Yayi; Gao, Xiaoxing; Aljarallah, Salman; Eubanks, James H.; McDonald, Robert J.; Zhang, Liang (Public Library of ScienceArts and ScienceDepartment of NeuroscienceToronto Western Research InstituteUniversity of TorontoUniversity of LethbridgeKing Saud Universityhttps://dx.doi.org/10.1371/journal.pone.0144113, 2015)
    Aging is associated with an increased risk of seizures/epilepsy. Stroke(ischemic or hemorrhagic) and cardiac arrest related brain injury are two major causative factors for seizure development in this patient population. ...
  • Burke, Candace J.; Kisko, Theresa M.; Swiftwolfe, Hilarie; Pellis, Sergio M.; Euston, David R. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceUniversity of LethbridgePhilipps-University of Marburghttps://doi.org/10.1371/journal.pone.0175841, 2017)
    Rat ultrasonic vocalizations have been suggested to be either a byproduct of physical movement or, in the case of 50-kHz calls, a means to communicate positive affect. Yet there are up to 14 distinct types of 50-kHz calls, ...
  • Jafari, Zahra; Mehla, Jogender; Afrashteh, Navvab; Kolb, Bryan E.; Mohajerani, Majid H. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceUniversity of LethbridgeIran University of Medical Science (IUMS), 2017)
    Maternal stress is a common adversity during pregnancy. Gestational corticosterone alternations are thought to contribute to the etiology of postpartum behavioral disturbances. However, the impact of stress during pregnancy, ...
  • Hambrook, Dillon A.; Ilievski, Marko; Mosadeghzad, Mohamad; Tata, Matthew S. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceUniversity of Lethbridge, 2017)
    The process of resolving mixtures of several sounds into their separate individual streams is known as auditory scene analysis and it remains a challenging task for computational systems. It is well-known that animals use ...
  • Chalmers, Eric; Luczak, Artur; Gruber, Aaron J. (Frontiers MediaArts and ScienceDepartment of NeuroscienceUniversity of Lethbridge, 2016)
    The mammalian brain is thought to use a version of Model-based Reinforcement Learning (MBRL) to guide “goal-directed” behavior, wherein animals consider goals and make plans to acquire desired outcomes. However, conventional ...
  • Gidyk, Darryl C.; Deibel, Scott H.; Hong, Nancy S.; McDonald, Robert J. (Frontiers MediaArts and ScienceDepartment of NeuroscienceUniversity of Lethbridge, 2015)
    Sporadic Alzheimer’s disease (AD) is the most prevalent form of age-related dementia. As such, great effort has been put forth to investigate the etiology, progression, and underlying mechanisms of the disease. Countless ...
  • Wilber, Aaron A.; Clark, Benjamin J.; Demecha, Alexis J.; Mesina, Lilia; Vos, Jessica M.; McNaughton, Bruce L. (Frontiers MediaArts and ScienceDepartment of NeuroscienceUniversity of LethbridgeUniversity of CaliforniaUniversity of New Mexico, 2014)
    A central feature of theories of spatial navigation involves the representation of spatial relationships between objects in complex environments. The parietal cortex has long been linked to the processing of spatial visual ...

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