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dc.contributor.supervisor Gibb, Robbin L.
dc.contributor.supervisor Kolb, Bryan
dc.contributor.author Raza, Sarah
dc.date.accessioned 2015-05-25T16:22:01Z
dc.date.available 2015-05-25T16:22:01Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/10133/3690
dc.description.abstract Autism is a behaviorally defined neurodevelopmental disorder characterized by qualitative impairments in social interaction, communication, and aberrant repetitive behaviors. Behavioral phenotyping in laboratory animals to simulate core symptomology has been a large research focus with the aim to not only elucidate the behavioral basis and neural underpinnings of the disorder, but also study potential remedial treatments. The present thesis evaluated the validity of the valproic acid (VPA) rat model of autism by examining perturbations in the neurodevelopmental trajectories – behavioral and neurobiological – of juvenile and adult rats prenatally exposed to VPA, as well as the therapeutic effects of early tactile stimulation on the synergistic brain-behavior relationship. Behavioral and neuroanatomical findings confirmed the face, construct, and predictive validity of the VPA rat model, given the ethological, etiological, and therapeutic similarities to facets of human autism; thus, reinforcing the VPA model as a viable model for the study of autism in rats. en_US
dc.description.sponsorship Natural Sciences and Engineering Research Council of Canada (NSERC), Alberta Health Innovates Health Solutions (AIHS),Canadian Institute for Advanced Research Program in Child Brain Development en_US
dc.language.iso en_CA en_US
dc.publisher Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience en_US
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en_US
dc.subject Valproic Acid en_US
dc.subject Autism en_US
dc.subject Brain Development en_US
dc.subject Behavior en_US
dc.title The effect of prenatal valproic acid exposure on the developing brain : face, construct, and predictive validity of an animal model of autism en_US
dc.type Thesis en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Neuroscience en_US
dc.degree.level Masters en_US
dc.proquest.subject 0317 en_US
dc.proquest.subject 0602 en_US
dc.proquest.subject 0349 en_US
dc.proquestyes Yes en_US
dc.embargo No en_US


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