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dc.contributor.supervisor Euston, David R.
dc.contributor.supervisor McDonald, Robert J.
dc.contributor.author Holec, Victoria
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2014-05-29T22:48:32Z
dc.date.available 2014-05-29T22:48:32Z
dc.date.issued 2013
dc.identifier.uri https://hdl.handle.net/10133/3433
dc.description xii, 177 leaves : ill. ; 29 cm en_US
dc.description.abstract When given a choice between getting a high reward that requires climbing a high ramp or pressing a lever multiple times, versus freely obtaining a low reward, healthy rats prefer the former, while rats with lesions to the anterior cingulate cortex (ACC) prefer the latter. We developed two novel effort tasks to examine if ACC mediates other types of physical effort (weight-lifting) as well as emotional effort (courage). We replicated previous findings on a modified version of the ramp-climbing task, showing that ACC lesions impair these decisions. Lesions of ACC did not impair weight-lifting effort, even when higher levels of effort were used and training on the task was eliminated. Initially, lesions of ACC did not impair courage effort. When the task effort was subsequently increased, rats with ACC lesions showed a failure to adapt to novelty throughout testing. This research indicated that not all effort is mediated by ACC. en_US
dc.language.iso en_CA en_US
dc.publisher Lethbridge, Alta. : University of Lethbridge, [Dept. of] Neuroscience, c2013 en_US
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en_US
dc.subject Rats -- Behavior en_US
dc.subject Prefrontal cortex -- Physiology en_US
dc.subject Brain -- Research en_US
dc.subject Decision making -- Physiological aspects en_US
dc.subject Rats as laboratory animals en_US
dc.subject Dissertations, Academic en_US
dc.title Role of rat anterior cingulate cortex in effort- and courage-based decision making en_US
dc.type Thesis en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Neuroscience en_US
dc.degree.level Masters en_US
dc.proquestyes No en_US


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