Role of rat anterior cingulate cortex in effort- and courage-based decision making

Simple item page
dc.contributor.authorHolec, Victoria
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorEuston, David R.
dc.contributor.supervisorMcDonald, Robert J.
dc.date.accessioned2014-05-29T22:48:32Z
dc.date.available2014-05-29T22:48:32Z
dc.date.issued2013
dc.degree.levelMastersen_US
dc.descriptionxii, 177 leaves : ill. ; 29 cmen_US
dc.description.abstractWhen given a choice between getting a high reward that requires climbing a high ramp or pressing a lever multiple times, versus freely obtaining a low reward, healthy rats prefer the former, while rats with lesions to the anterior cingulate cortex (ACC) prefer the latter. We developed two novel effort tasks to examine if ACC mediates other types of physical effort (weight-lifting) as well as emotional effort (courage). We replicated previous findings on a modified version of the ramp-climbing task, showing that ACC lesions impair these decisions. Lesions of ACC did not impair weight-lifting effort, even when higher levels of effort were used and training on the task was eliminated. Initially, lesions of ACC did not impair courage effort. When the task effort was subsequently increased, rats with ACC lesions showed a failure to adapt to novelty throughout testing. This research indicated that not all effort is mediated by ACC.en_US
dc.identifier.urihttps://hdl.handle.net/10133/3433
dc.language.isoen_CAen_US
dc.proquestyesNoen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, [Dept. of] Neuroscience, c2013en_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectRats -- Behavioren_US
dc.subjectPrefrontal cortex -- Physiologyen_US
dc.subjectBrain -- Researchen_US
dc.subjectDecision making -- Physiological aspectsen_US
dc.subjectRats as laboratory animalsen_US
dc.subjectDissertations, Academicen_US
dc.titleRole of rat anterior cingulate cortex in effort- and courage-based decision makingen_US
dc.typeThesisen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
HOLEC_VICTORIA_MSC_2013.pdf
Size:
23.68 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.63 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Arts and Science, Faculty of
University of Lethbridge Theses