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dc.contributor.supervisor Sutherland, Robert J.
dc.contributor.author Cardiff, James W
dc.date.accessioned 2014-01-20T22:55:02Z
dc.date.available 2014-01-20T22:55:02Z
dc.date.issued 2012
dc.identifier.uri https://hdl.handle.net/10133/3356
dc.description vii, 60 leaves : ill. (some col.) ; 29 cm en_US
dc.description.abstract Adrenalectomy (ADX) has been shown to cause selective degeneration of granule cells in the dentate gyrus (DG). This occurs due to the reduction of corticosterone (CORT) and behavioural deficits are associated with the loss of these neurons. Dentate lesions and cell loss associated with ADX have been shown to effect behaviour in a number of spatial tasks. In contras, it has been shown granule cell loss does not affect the specificity of place cells in CA3 and CA1. We used the ADX model to examine the role of DG granule cells plays in representing space using immediate early gene (IEG) activation in the principal hippocampal subfields after exploration of novel environments. Rats were allowed to free explore multiple novel environments and then the mRNA for the IEG Homer 1a (H1a) was used as a marker of neural activity. After degeneration of approximately half of the DG granule cells we found a significant increase in number of active cells in the DG, CA3 and CA1 in ADX animals. The results indicate a reduction in granule cells causes a dramatic increase in the proportion of remaining DG granule cells in response to exploration. The change in DG activation disrupts the representations in CA3 and CA1 and thereby affects behaviour. en_US
dc.language.iso en_CA en_US
dc.publisher Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, c2012 en_US
dc.subject Dentate gyrus -- Research en_US
dc.subject Hippocampus (Brain) -- Research en_US
dc.subject Gene expression -- Research en_US
dc.subject Adrenalectomy en_US
dc.subject Neuroplasticity -- Research en_US
dc.subject Rats as laboratory animals en_US
dc.subject Dissertations, Academic en_US
dc.title Experienced-induced immediate early gene expression in hippocampus after granule cell loss en_US
dc.type Thesis en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Neuroscience en_US
dc.degree.level Masters


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