Sutherland, Robert

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A novel animal model of hippocampal cognitive deficits, slow neurodegeneration, and neuroregeneration
(Hindawi Publishing, 2011) Spanswick, Simon C.; Lehmann, Hugo; Sutherland, Robert J.
Long-term adrenalectomy (ADX) results in an extensive and speciﬁc loss of dentate gyrus granule cells in the hippocampus of adult rats. This loss of granule cells extends over a period of weeks to months and ultimately results in cognitive deﬁcits revealed in a number of tasks that depend on intact hippocampal function. The gradual nature of ADX-induced cell death and the ensuing deﬁcits in cognition resemble in some important respects a variety of pathological conditions in humans. Here, we characterize behavioural and cellular processes, including adult neurogenesis, in the rat ADX model.We also provide experimental evidence for a neurogenic treatment strategy by which the lost hippocampal cells may be replaced, with the goal of functional recovery in mind.