Kolb, Bryan

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https://opus.uleth.ca/handle/10133/4575

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Browsing Kolb, Bryan by Subject "Brain plasticity"

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    Factors influencing cerebral plasticity in the normal and injured brain
    (Frontiers Research Foundation, 2010) Kolb, Bryan; Teskey, G. Campbell; Gibb, Robbin L.
    An important development in behavioral neuroscience in the past 20 years has been the demonstration that it is possible to stimulate functional recovery after cerebral injury in laboratory animals. Rodent models of cerebral injury provide an important tool for developing such rehabilitation programs. The models include analysis at different levels including detailed behavioral paradigms, electrophysiology, neuronal morphology, protein chemistry, and epigenetics. A significant challenge for the next 20 years will be the translation of this work to improve the outcome from brain injury and disease in humans. Our goal in the article will be to synthesize the multidisciplinary laboratory work on brain plasticity and behavior in the injured brain to inform the development of rehabilitation programs.
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    Harnessing the power of neuroplasticity for intervention
    (Frontiers Media, 2014) Kolb, Bryan; Muhammad, Arif
    A fundamental property of the brain is its capacity to change with a wide variety of experiences, including injury. Although there are spontaneous reparative changes following injury, these changes are rarely sufficient to support significant functional recovery. Research on the basic principles of brain plasticity is leading to new approaches to treating the injured brain. We review factors that affect synaptic organization in the normal brain, evidence of spontaneous neuroplasticity after injury, and the evidence that factors including postinjury experience, pharmacotherapy, and cell-based therapies, can form the basis of rehabilitation strategies after brain injuries early in life and adulthood.