Factors influencing cerebral plasticity in the normal and injured brain

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Kolb, Bryan
Teskey, G. Campbell
Gibb, Robbin L.
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Frontiers Research Foundation
An important development in behavioral neuroscience in the past 20 years has been the demonstration that it is possible to stimulate functional recovery after cerebral injury in laboratory animals. Rodent models of cerebral injury provide an important tool for developing such rehabilitation programs. The models include analysis at different levels including detailed behavioral paradigms, electrophysiology, neuronal morphology, protein chemistry, and epigenetics. A significant challenge for the next 20 years will be the translation of this work to improve the outcome from brain injury and disease in humans. Our goal in the article will be to synthesize the multidisciplinary laboratory work on brain plasticity and behavior in the injured brain to inform the development of rehabilitation programs.
Sherpa Romeo green journal: open access
Brain plasticity , Recovery of function , Cerebral cortex , Brain--Wounds and injuries , Neuroplasticity , Brain damage--Animal models
Kolb, B., Teskey, G. C., & Gibb, R. (2010). Factors influencing cerebral plasticity in the normal and injured brain. Frontiers in Human Neuroscience, 4(204). doi:10.3389/fnhum.2010.00204