Faculty Research and Publications

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Browsing Faculty Research and Publications by Subject "Adrenalectomy"

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    A novel animal model of hippocampal cognitive deficits, slow neurodegeneration, and neuroregeneration
    (Hindawi Publishing, 2011) Spanswick, Simon C.; Lehmann, Hugo; Sutherland, Robert J.
    Long-term adrenalectomy (ADX) results in an extensive and specific loss of dentate gyrus granule cells in the hippocampus of adult rats. This loss of granule cells extends over a period of weeks to months and ultimately results in cognitive deficits revealed in a number of tasks that depend on intact hippocampal function. The gradual nature of ADX-induced cell death and the ensuing deficits in cognition resemble in some important respects a variety of pathological conditions in humans. Here, we characterize behavioural and cellular processes, including adult neurogenesis, in the rat ADX model.We also provide experimental evidence for a neurogenic treatment strategy by which the lost hippocampal cells may be replaced, with the goal of functional recovery in mind.
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    Object/context-specific memory deficits associated with loss of hippocampal granule cells after adrenalectomy in rats
    (Cold Spring Harbor Laboratory Press, 2010) Spanswick, Simon C.; Sutherland, Robert J.
    Chronic adrenalectomy (ADX) causes a gradual and selective loss of granule cells in the dentate gyrus (DG) of the rat.Here, we administered replacement corticosterone to rats beginning 10wk after ADX. We then tested them in three discrimination tasks based on object novelty, location, or object/context association. Only during testing of the object/context association did ADX rats demonstrate deficits. These findings add to a body of evidence that the hippocampus is necessary when contextual information is important.We also confirm that memory deficits after chronic adrenalectomy are not a result of loss of corticosterone per se.