Amphetamine-induced changes in arousal and locomotion and their effects in neural signaling in the retrosplenial cortex

Simple item page
dc.contributor.authorLeon, Rebeca
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorGruber, Aaron J.
dc.date.accessioned2021-09-10T13:53:17Z
dc.date.available2021-09-10T13:53:17Z
dc.date.issued2021
dc.degree.levelMastersen_US
dc.description.abstractChanges in neural activity induced by amphetamine (AMPH) are thought to be a direct effect of the drug. However, this may be an artifact of motoric output and/or arousal. Here, we used a model of chronic AMPH taking to provide evidence that variations in retrosplenial cortex (RSC) activity are attributable to changes in running speed and pupil area. We show that speed is the best predictor of the average neural activity variance, whereas pupil area makes smaller contributions. Moreover, we found that the relationship between these parameters and neural activity is unaltered during AMPH administration or discontinuation. In other words, AMPH evokes changes in neural activity by changing motoric output and arousal, and not by changing the sensitivity of neural activity to these. Our results provide evidence of the potential for psychostimulants to alter neural activity via movement, and they highlight the importance of motion tracking.en_US
dc.identifier.urihttps://hdl.handle.net/10133/6018
dc.language.isoen_USen_US
dc.proquest.subjectBiology [0306]en_US
dc.proquest.subjectNeurosciences [0317]en_US
dc.proquest.subjectPharmacology [0419]en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Neuroscienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectPsychostimulantsen_US
dc.subjectAmphetaminesen_US
dc.subjectArousal (Physiology)en_US
dc.subjectDissertations, Academicen_US
dc.subjectNeocortexen_US
dc.subjectPupillometryen_US
dc.subjectRunning speeden_US
dc.subjectStimulantsen_US
dc.titleAmphetamine-induced changes in arousal and locomotion and their effects in neural signaling in the retrosplenial cortexen_US
dc.typeThesisen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
LEON_REBECA_MSC_2021.pdf
Size:
2.4 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
3.25 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Arts and Science, Faculty of
University of Lethbridge Theses