Molecular mechanisms of viral hepatitis induced hepatocellular carcinoma

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dc.contributor.authorD'Souza, Simmone
dc.contributor.authorLau, Keith C. K.
dc.contributor.authorCoffin, Carla S.
dc.contributor.authorPatel, Trushar R.
dc.date.accessioned2023-02-07T16:56:30Z
dc.date.available2023-02-07T16:56:30Z
dc.date.issued2020
dc.descriptionOpen access article. Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0) appliesen_US
dc.description.abstractChronic infection with viral hepatitis affects half a billion individuals worldwide and can lead to cirrhosis, cancer, and liver failure. Liver cancer is the third leading cause of cancer-associated mortality, of which hepatocellular carcinoma (HCC) represents 90% of all primary liver cancers. Solid tumors like HCC are complex and have heterogeneous tumor genomic profiles contributing to complexity in diagnosis and management. Chronic infection with hepatitis B virus (HBV), hepatitis delta virus (HDV), and hepatitis C virus (HCV) are the greatest etiological risk factors for HCC. Due to the significant role of chronic viral infection in HCC development, it is important to investigate direct (viral associated) and indirect (immune-associated) mechanisms involved in the pathogenesis of HCC. Common mechanisms used by HBV, HCV, and HDV that drive hepatocarcinogenesis include persistent liver inflammation with an impaired antiviral immune response, immune and viral protein-mediated oxidative stress, and deregulation of cellular signaling pathways by viral proteins. DNA integration to promote genome instability is a feature of HBV infection, and metabolic reprogramming leading to steatosis is driven by HCV infection. The current review aims to provide a brief overview of HBV, HCV and HDV molecular biology, and highlight specific viral-associated oncogenic mechanisms and common molecular pathways deregulated in HCC, and current as well as emerging treatments for HCC.en_US
dc.identifier.citationD'Souza,S., Lau, K. C. K., Coffin, C. S., & Patel, T. R. (2020). Molecular mechanisms of viral hepatitis induced hepatocellular carcinoma. World Journal of Gastroenterology, 26(38), 5745-5910. https://www.wjgnet.com/1007-9327/full/v26/i38/5759.htmen_US
dc.identifier.urihttps://hdl.handle.net/10133/6428
dc.language.isoen_USen_US
dc.publisherBaishideng Publishingen_US
dc.publisher.departmentDepartment of Chemistry and Biochemistry
dc.publisher.facultyArts and Science
dc.publisher.institutionUniversity of Lethbridge
dc.publisher.urlhttps://www.wjgnet.com/1007-9327/full/v26/i38/5759.htm
dc.subjectChronic viral infectionen_US
dc.subjectHallmarks of canceren_US
dc.subjectHepatocellular carcinomaen_US
dc.subjectHepatitis delta virus co-infectionen_US
dc.subjectMolecular mechanismsen_US
dc.subjectViral hepatitisen_US
dc.subject.lcshLiver--Cancer
dc.subject.lcshHepatitis B virus
dc.subject.lcshHepatitis C virus
dc.subject.lcshDelta-associated agent
dc.subject.lcshHepatitis, Viral
dc.titleMolecular mechanisms of viral hepatitis induced hepatocellular carcinomaen_US
dc.typeArticleen_US
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