Host transcription factors in hepatitis B virus RNA synthesis

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dc.contributor.authorTurton, Kristi L.
dc.contributor.authorMeier-Stephenson, Vanessa
dc.contributor.authorBadmalia, Maulik D.
dc.contributor.authorCoffin, Carla S.
dc.contributor.authorPatel, Trushar R.
dc.date.accessioned2023-02-08T22:39:52Z
dc.date.available2023-02-08T22:39:52Z
dc.date.issued2020
dc.descriptionOpen access article. Creative Commons Attribution 4.0 International License (CC BY 4.0) appliesen_US
dc.description.abstractThe hepatitis B virus (HBV) chronically infects over 250 million people worldwide and is one of the leading causes of liver cancer and hepatocellular carcinoma. HBV persistence is due in part to the highly stable HBV minichromosome or HBV covalently closed circular DNA (cccDNA) that resides in the nucleus. As HBV replication requires the help of host transcription factors to replicate, focusing on host protein–HBV genome interactions may reveal insights into new drug targets against cccDNA. The structural details on such complexes, however, remain poorly defined. In this review, the current literature regarding host transcription factors’ interactions with HBV cccDNA is discussed.en_US
dc.identifier.citationTurton, K. L., Meier-Stephenson, V., Badmalia, M. D., Coffin, C. S., & Patel, T. R. (2020). Host transcription factors in hepatitis B virus RNA synthesis. Viruses, 12(2), 160. https://doi.org/10.3390/v12020160en_US
dc.identifier.urihttps://hdl.handle.net/10133/6430
dc.language.isoen_CAen_US
dc.publisherMDPIen_US
dc.publisher.departmentDepartment of Chemistry and Biochemistry
dc.publisher.facultyArts and Science
dc.publisher.institutionUniversity of Lethbridge
dc.publisher.institutionUniversity of Calgary
dc.publisher.institutionUniversity of Alberta
dc.publisher.urlhttps://doi.org/10.3390/v12020160
dc.subjectHepatitis B virus (HBV)en_US
dc.subjectViral replicationen_US
dc.subjectCovalently closed circular DNA (cccDNA)en_US
dc.subjectHost-viral interactionsen_US
dc.subject.lcshHepatitis B virus
dc.subject.lcshViruses--Reproduction
dc.subject.lcshTranscription factors
dc.subject.lcshCircular DNA
dc.subject.lcshHost-virus relationships
dc.titleHost transcription factors in hepatitis B virus RNA synthesisen_US
dc.typeArticleen_US
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