Recovery of function after cingulate cortex injury in rats

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dc.contributor.authorGonzalez, Claudia L. R.
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorKolb, Bryan
dc.date.accessioned2007-04-25T14:40:50Z
dc.date.available2007-04-25T14:40:50Z
dc.date.issued2000
dc.degree.levelMasters
dc.descriptionix, 111 leaves : ill. ; 29 cm.en
dc.description.abstractThe current studies investigate the behavioral and anatomical changes after lesions at different ages of the cingulate cortex. Rats received lesions of the posterior cingulate cortex (PCing) or the anterior and posterior cingulate cortex (Total) at: postnatal day 4 (P4); day 10 (P10), or in adulthood (P120). Rats were trained in the Morris water maze, the Whishaw reaching task, conditioned taste aversion (CTA), and their activity was monitored over 48 hours. The general finding was a significant behavioral recovery on P10 animals regardless the size of the lesion. This recovery was associated with an increase in dendritic arborization in P10 animals with the PCing removed and a partial regeneration of the midline tissue in the Total P10 animals. These results suggest that damage to the cingulate cortex at P10 is associated with substantial behavioral and anatomical plasticity and that removal of the frontal midline tissue stimulates a regenerative process in more posterior cortex that does not occur otherwise.en
dc.identifier.urihttps://hdl.handle.net/10133/118
dc.language.isoen_USen
dc.publisherLethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2000en
dc.publisher.departmentDepartment of Neuroscience
dc.publisher.facultyArts and Science
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en
dc.subjectDissertations, Academicen
dc.subjectPrefrontal cortex -- Physiologyen
dc.subjectPrefrontal cortex -- Wounds and injuriesen
dc.subjectRats as laboratory animalsen
dc.subjectNeurobiologyen
dc.titleRecovery of function after cingulate cortex injury in ratsen
dc.typeThesisen
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